Jessica McGillen
 Jessica McGillenMS Computational Biology, BS Biological Sciences, Carnegie Mellon University
eMail:
Jessica [dot] McGillen [-at-] maths [dot] ox [dot] ac [dot] uk
Reception/Secretary: +44 1865 273525 Office: DH56 Departmental Address:
Mathematical Institute |
Research Interests:
My interests are in modelling the metabolism and behaviour of developing solid tumours in the context of the tissue microenvironment, with the aim of elucidating the drivers and consequences of energy metabolism reprogramming. Of particular interest is the acid-mediated invasion hypothesis, which suggests that a critical stage in tumour progression from benign to malignant growth comprises tissue hypoxia, adoption of the glycolytic phenotype, and acquisition of resistance to acidic byproducts of the glycolytic phenotype. Many open questions remain concerning the details of this hypothesis and its role in the somatic evolution of cancer, illustrating just one of many research avenues for modelling the somatic evolution of cancer in general. Prizes, Awards and Scholarships:
Overseas Graduate Scholarship, St. Catherine's College, Oxford University, Oxford, UK (October 2011-present). Travel grant from the European Society for Mathematical and Theoretical Biology to present a poster at the 8th European Conference on Mathematical and Theoretical Biology, Krakow, Poland (June 2011). Certificate of Merit for Outstanding Undergraduate Research in Biological Sciences, Carnegie Mellon University, Pittsburgh, PA, USA (May 2006). Major/Recent Publications:
McGillen JB, Gaffney EA, Martin NK, Maini PK. A generalised model of acid-mediated tumour invasion, in preparation. McGillen JB, Martin NK, Robey IF, Gaffney EA, Maini PK. Applications of mathematical analysis to tumour acidity modelling. RIMS Kokyuroku Bessatsu, in press. Teaching:
Oxford University Teaching Assistant for C8.1b Mathematical Physiology (2011-2012) Teaching Assistant for B8a Mathematical Ecology and Biology (2010-2011) Teaching Assistant for C6.3a Perturbation Methods (2010) Further Details:
Selected presentations Talk: 'Mathematical modelling of tumour acidity and invasion', Inaugural meeting of the St. Catherine's College Biomedical Society, Oxford University, Oxford, UK (November 2011). Poster: 'Mathematical modelling of cancer ecology', 8th European Conference on Mathematical and Theoretical Biology, Krakow, Poland (June 2011). Talk: 'Modelling acid-mediated tumour invasion', Group meeting, Centre for Mathematical Biology, Mathematical Institute, Oxford University, Oxford, UK (May 2011). |
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