Past Special Lecture

8 June 2018
16:00
to
18:00
Philip Maini, Edward Morrissey, Heather Harrington
Abstract

1600-1645 - Philip Maini
1645-1705 - Edward Morrissey
1705-1725 - Heather Harrington
1725-1800 - Drinks and networking

The talks will be followed by a drinks reception.

Tickets can be obtained from https://www.eventbrite.co.uk/e/qbiox-colloquium-trinity-term-2018-ticket....
(As ever, tickets are not necessary, but they do help in judging catering requirements.)

PHILIP MAINI

Does mathematics have anything to do with biology? In this talk, I will review a number of interdisciplinary collaborations in which I have been involved over the years that have coupled mathematical modelling with experimental studies to try to advance our understanding of processes in biology and medicine. Examples will include somatic evolution in tumours, collective cell movement in epithelial sheets, cell invasion in neural crest, and pattern formation in slime mold. These are examples where verbal reasoning models are misleading and insufficient, while mathematical models can enhance our intuition.

EDWARD MORRISEY

Fixation and spread of somatic mutations in adult human colonic epithelium Cancer causing mutations must become permanently fixed within tissues. I will describe how, by visualizing somatic clones, we investigated the means and timing with which this occurs in the human colonic epithelium. Modelling the effects of gene mutation, stem cell dynamics and subsequent lateral expansion revealed that fixation required two sequential steps. First, one of around seven active stem cells residing within each colonic gland has to be mutated. Second, the mutated stem cell has to replace neighbours to populate the entire gland. This process takes many years because stem cell replacement is infrequent (around once every 9 months). Subsequent clonal expansion due to gland fission is also rare for neutral mutations. Pro-oncogenic mutations can subvert both stem cell replacement to accelerate fixation and clonal expansion by gland fission to achieve high mutant allele frequencies with age. The benchmarking and quantification of these behaviours allows the advantage associated with different gene specific mutations to be compared and ranked irrespective of the cellular mechanisms by which they are conferred. The age related mutational burden of advantaged mutations can be predicted on a gene-by-gene basis to identify windows of opportunity to affect fixation and limit spread.

HEATHER HARRINGTON

Comparing models with data using computational algebra In this talk I will discuss how computational algebraic geometry and topology can be useful for studying questions arising in systems biology. In particular I will focus on the problem of comparing models and data through the lens of computational algebraic geometry and statistics. I will provide concrete examples of biological signalling systems that are better understood with the developed methods.

11 May 2018
15:00
to
16:30
Claudia Silva & Oscar Garcia-Prada
Abstract

Oscar García-Prada - The Mathematics of Kolam

In Tamil Nadu, a state in southern India, it is an old tradition to decorate the entrance to the home with a geometric figure called ``Kolam''. A kolam is a geometrical line drawing composed of curved loops, drawn around a grid pattern of dots. This is typically done by women using white rice flour. Kolams have connections to discrete mathematics, number theory, abstract algebra, sequences, fractals and computer science. After reviewing a bit of its history, Oscar will explore some of these connections. 

Claudia Silva - Kolam: An Ephemeral Women´s art of South India

Kolam is a street drawing, performed by women in south India. This daily ritual of "putting" the kolam on the ground represents a time of intimacy, concentration and creativity. Through some videos, Claudia will explain some basic features of kolam, focusing on anthropological, religious, educational and artistic aspects of this beautiful female art expression.

The lectures are accompanied by a photography exhibition at Wolfson College.

22 March 2018
09:00
to
17:00
Marie Hicks, Adrian Johnstone, Cliff Jones, Julianne Nyhan, Mark Priestly, Reinhard Siegmund-Schultze
Abstract

The BSHM meeting on “The history of computing beyond the computer” looks at the people and the science underpinning modern software and programming, from Charles Babbage’s design notation to forgotten female pioneers.

Registration will be £32.50 for standard tickets, £22.00 for BSHM members and Oxford University staff, and £6.50 for students. This will include tea/coffee and biscuits at break times, but not lunch, as we wanted to keep the registration fee to a minimum. A sandwich lunch or a vegetarian sandwich lunch can be ordered separately on the Eventbrite page. If you have other dietary requirements, please use the contact button at the bottom of this page. There is also a café in the Mathematical Institute that sells hot food at lunchtime, alongside sandwiches and snacks, and there are numerous places to eat within easy walking distance.

https://www.eventbrite.co.uk/e/the-history-of-computing-beyond-the-compu...

Programme

21 March 2018

17:00 Andrew Hodges, University of Oxford, author of "Alan Turing: The Enigma” on 'Alan Turing: soft machine in a hard world.’
http://www.turing.org.uk/index.html

22 March 2018

9:00 Registration

9:30 Adrian Johnstone, Royal Holloway University of London, on Charles Babbage's design notation
http://blog.plan28.org/2014/11/babbages-language-of-thought.html

10:15 Reinhard Siegmund-Schultze, Universitetet i Agder, on early numerical methods in the analysis of the Northern Lights
https://www.uia.no/kk/profil/reinhars

11:00 Tea/Coffee

11:30 Julianne Nyhan, University College London, on Father Busa and humanities data
https://archelogos.hypotheses.org/135

12:15 Cliff Jones, University of Newcastle, on the history of programming language semantics
http://homepages.cs.ncl.ac.uk/cliff.jones/

13:00 Lunch

14:00 Mark Priestley, author of "ENIAC in Action, Making and Remaking the Modern Computer"
http://www.markpriestley.net

14:45 Marie Hicks, University of Wisconsin-Madison, author of "Programmed Inequality: How Britain Discarded Women Technologists and Lost Its Edge In Computing"
http://mariehicks.net

15:30 Tea/Coffee

16:00 Panel discussion to include Martin Campbell-Kelly (Warwick), Andrew Herbert (TNMOC), and Ursula Martin (Oxford)

17:00 End of conference

Co-located event

23 March, in Mathematical Institute, University of Oxford, Symposium for the History and Philosophy of Programming, HaPoP 2018, Call for extended abstracts
http://www.hapoc.org/node/241

 

2 February 2018
17:15
Tom Nichols
Abstract

Today, everyone knows everything: with only a quick trip through WebMD or Wikipedia, average citizens believe themselves to be on an equal intellectual footing with doctors and diplomats. All voices, even the most ridiculous, demand to be taken with equal seriousness, and any claim to the contrary is dismissed as undemocratic elitism. Tom Nichols argues that in this climate, democratic institutions themselves are in danger of falling either to populism or to technocracy- or in the worst case, a combination of both.

Tom Nichols is Professor of National Security Affairs at the US Naval War College, an adjunct professor at the Harvard Extension School, and a former aide in the U.S. Senate. His latest book is The Death of Expertise: The Campaign Against Established Knowledge and Why it Matters. This lecture is based on that book.

All welcome. No need to book.

15 January 2018
13:00
to
17:00
Andrew Wiles, Irene Fonseca, John Rognes
Abstract

Timetable:

1.00pm: Introductory Remarks by Camilla Serck-Hanssen, the Vice President of the Norwegian Academy of Science and Letters

1.10pm - 2.10pm: Andrew Wiles

2.10pm - 2.30pm: Break

2.30pm - 3.30pm: Irene Fonseca

3.30pm - 4.00pm: Tea and Coffee

4.00pm - 5.00pm: John Rognes

Abstracts:

Andrew Wiles: Points on elliptic curves, problems and progress

This will be a survey of the problems concerned with counting points on elliptic curves.

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Irene Fonseca: Mathematical Analysis of Novel Advanced Materials

Quantum dots are man-made nanocrystals of semiconducting materials. Their formation and assembly patterns play a central role in nanotechnology, and in particular in the optoelectronic properties of semiconductors. Changing the dots' size and shape gives rise to many applications that permeate our daily lives, such as the new Samsung QLED TV monitor that uses quantum dots to turn "light into perfect color"! 

Quantum dots are obtained via the deposition of a crystalline overlayer (epitaxial film) on a crystalline substrate. When the thickness of the film reaches a critical value, the profile of the film becomes corrugated and islands (quantum dots) form. As the creation of quantum dots evolves with time, materials defects appear. Their modeling is of great interest in materials science since material properties, including rigidity and conductivity, can be strongly influenced by the presence of defects such as dislocations. 

In this talk we will use methods from the calculus of variations and partial differential equations to model and mathematically analyze the onset of quantum dots, the regularity and evolution of their shapes, and the nucleation and motion of dislocations.

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John Rognes: Symmetries of Manifolds

To describe the possible rotations of a ball of ice, three real numbers suffice.  If the ice melts, infinitely many numbers are needed to describe the possible motions of the resulting ball of water.  We discuss the shape of the resulting spaces of continuous, piecewise-linear or differentiable symmetries of spheres, balls and higher-dimensional manifolds.  In the high-dimensional cases the answer turns out to involve surgery theory and algebraic K-theory.

3 November 2017
17:00
to
18:15
The Annual Charles Simonyi Lecture - Geoffrey West
Abstract

In this year’s Simonyi Lecture, Geoffrey West discusses the universal laws that govern everything from the growth of plants and animals to cities and corporations. These laws help us to answer big, urgent questions about global sustainability, population explosion, urbanization, ageing, cancer, human lifespans and the increasing pace of life.

Why can we live for 120 years but not for a thousand? Why do mice live for just two or three years and elephants for up to 75? Why do companies behave like mice, and are they all destined to die? Do cities, companies and human beings have natural, pre-determined lifespans?

Geoffrey West is a theoretical physicist whose primary interests have been in fundamental questions in physics and biology. West is a Senior Fellow at Los Alamos National Laboratory and a distinguished professor at the Sante Fe Institute, where he served as the president from 2005-2009. In 2006 he was named to Time’s list of The 100 Most Influential People in the World.

This lecture will take place at the Oxford Playhouse, Beaumont Street. Book here

 

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