Author
Bacik, K
Schaub, M
Beguerisse-Díaz, M
Billeh, Y
Barahona, M
Journal title
PLoS computational biology
Issue
8
Volume
12
Last updated
2021-11-25T01:34:31.333+00:00
Page
e1005055-e1005055
Abstract
We exploit flow propagation on the directed neuronal network of the nematode C. elegans to reveal dynamically relevant features of its connectome. We find flow-based groupings of neurons at different levels of granularity, which we relate to functional and anatomical constituents of its nervous system. A systematic in silico evaluation of the full set of single and double neuron ablations is used to identify deletions that induce the most severe disruptions of the multi-resolution flow structure. Such ablations are linked to functionally relevant neurons, and suggest potential candidates for further in vivo investigation. In addition, we use the directional patterns of incoming and outgoing network flows at all scales to identify flow profiles for the neurons in the connectome, without pre-imposing a priori categories. The four flow roles identified are linked to signal propagation motivated by biological input-response scenarios.
Symplectic ID
638073
Publication type
Journal Article
Publication date
5 August 2016
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