Author
Wachter, K
Evans, S
Steinsaltz, D
Journal title
Proceedings of the National Academy of Sciences
DOI
10.1073/pnas.1306656110
Issue
25
Volume
110
Last updated
2022-03-14T14:51:06.707+00:00
Page
10141-10146
Abstract
<jats:p>W. D. Hamilton’s celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton’s setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane’s principle for genetic load has an exact but unfamiliar generalization.</jats:p>
Symplectic ID
403990
Publication type
Journal Article
Publication date
18 June 2013
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