Skeletal muscles as prototypes of active materials

Considerable attention has been recently focused on the study of muscle tissues viewed as prototypes of new materials that can actively generate stresses. The intriguing mechanical properties of such systems can be linked to hierarchical internal architecture. To complicate matters further, they are driven internally by endogenous mechanisms supplying energy and maintaining non-equilibrium.  In this talk we review the principal mechanisms of force generation in muscles and discuss the adequacy of the available mathematical models.