Feedback control is found extensively in many natural and technological systems. Indeed, many biological processes use feedback
to regulate key processes – examples include bacterial chemotaxis and negative autoregulation in genetic circuits. Despite the prevalence of
feedback in natural systems, its design and implementation in a Synthetic Biological context is much harder. In this talk I will give
examples of how we implemented feedback systems in three different biological systems. The first one concerns the design of a synthetic
recombinase-based feedback loop, which results into robust expression. The second describes the use of small RNAs to post-transcriptionally
regulate gene expression through interaction with messenger RNA (mRNA). The third involves the introduction of negative feedback in a
two-component signalling system through a controllable phosphatase. Closing, I will outline the challenges posed by the design of such
systems, both theoretical and on their implementation.
Seminar series
Date
Fri, 03 Nov 2017
Time
14:00 -
15:00
Location
L3
Speaker
Professor Antonis Papachristodoulou
Organisation
Dept of Engineering Science University of Oxford