Author
Arora, S
Visanji, N
Mestre, T
Tsanas, A
Aldakheel, A
Connolly, B
Gasca-Salas, C
Kern, D
Jain, J
Slow, E
Faust-Socher, A
Lang, A
Little, M
Marras, C
Journal title
Journal of Parkinson's Disease
DOI
10.3233/JPD-181389
Issue
4
Volume
8
Last updated
2022-03-05T06:58:13.843+00:00
Page
503-510
Abstract
We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated Parkinson’s disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts.
Symplectic ID
929591
Publication type
Journal Article
Publication date
17 October 2018
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