Author
Lord, L
Expert, P
Atasoy, S
Roseman, L
Rapuano, K
Lambiotte, R
Nutt, D
Deco, G
Carhart-Harris, R
Kringelbach, M
Ribeiro Barbosa Cabral, J
Journal title
NeuroImage
DOI
10.1016/j.neuroimage.2019.05.060
Volume
199
Last updated
2024-03-23T13:17:25.02+00:00
Page
127-142
Abstract
<p>Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns (‘functional brain networks’), which potentially underlie different mental processes.</p>

<p>The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in “magic mushrooms”. We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session.</p>

<p>Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.</p>
Symplectic ID
1002993
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Publication type
Journal Article
Publication date
25 May 2019
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