Dynamical exploration of the repertoire of brain networks at rest is modulated by psilocybin.

Author: 

Lord, L
Expert, P
Atasoy, S
Roseman, L
Rapuano, K
Lambiotte, R
Nutt, D
Deco, G
Carhart-Harris, R
Kringelbach, M
Cabral, J

Publication Date: 

October 2019

Journal: 

NeuroImage

Last Updated: 

2019-08-20T12:57:12.687+01:00

Volume: 

199

DOI: 

10.1016/j.neuroimage.2019.05.060

page: 

127-142

abstract: 

Growing evidence from the dynamical analysis of functional neuroimaging data suggests that brain function can be understood as the exploration of a repertoire of metastable connectivity patterns ('functional brain networks'), which potentially underlie different mental processes. The present study characterizes how the brain's dynamical exploration of resting-state networks is rapidly modulated by intravenous infusion of psilocybin, a tryptamine psychedelic found in "magic mushrooms". We employed a data-driven approach to characterize recurrent functional connectivity patterns by focusing on the leading eigenvector of BOLD phase coherence at single-TR resolution. Recurrent BOLD phase-locking patterns (PL states) were assessed and statistically compared pre- and post-infusion of psilocybin in terms of their probability of occurrence and transition profiles. Results were validated using a placebo session. Recurrent BOLD PL states revealed high spatial overlap with canonical resting-state networks. Notably, a PL state forming a frontoparietal subsystem was strongly destabilized after psilocybin injection, with a concomitant increase in the probability of occurrence of another PL state characterized by global BOLD phase coherence. These findings provide evidence of network-specific neuromodulation by psilocybin and represent one of the first attempts at bridging molecular pharmacodynamics and whole-brain network dynamics.

Symplectic id: 

1002993

Submitted to ORA: 

Submitted

Publication Type: 

Journal Article