Heterogeneity in Space and Time: Novel Dispersion Relations in Morphogenesis
Dr. Andrew Krause
Motivated by recent work with biologists, I will showcase some results on Turing instabilities in complex domains. This is scientifically related to understanding developmental tuning in the whiskers of mice, and in synthetic quorum-sensing patterning of bacteria. Such phenomena are typically modelled using reaction-diffusion systems of morphogens, and one is often interested in emergent spatial and spatiotemporal patterns resulting from instabilities of a homogeneous equilibrium. In comparison to the well-known effects of how advection or manifold structure impacts the modes which may become unstable in such systems, I will present results on instabilities in heterogeneous systems, reaction-diffusion systems on evolving manifolds, as well as layered reaction-diffusion systems. These contexts require novel formulations of classical dispersion relations, and may have applications beyond developmental biology, such as in understanding niche formation for populations of animals in heterogeneous environments. These approaches also help close the vast gap between the simplistic theory of instability-driven pattern formation, and the messy reality of biological development, though there is still much work to be done in concretely demonstrating such a theory's applicability in real biological systems.
Cavity flow characteristics and applications to kidney stone removal
Dr. Jessica Williams
Ureteroscopy is a minimally invasive surgical procedure for the removal of kidney stones. A ureteroscope, containing a hollow, cylindrical working channel, is inserted into the patient's kidney. The renal space proximal to the scope tip is irrigated, to clear stone particles and debris, with a saline solution that flows in through the working channel. We consider the fluid dynamics of irrigation fluid within the renal pelvis, resulting from the emerging jet through the working channel and return flow through an access sheath . Representing the renal pelvis as a two-dimensional rectangular cavity, we investigate the effects of flow rate and cavity size on flow structure and subsequent clearance time of debris. Fluid flow is modelled with the steady incompressible Navier-Stokes equations, with an imposed Poiseuille profile at the inlet boundary to model the jet of saline, and zero-stress conditions on the outlets. The resulting flow patterns in the cavity contain multiple vortical structures. We demonstrate the existence of multiple solutions dependent on the Reynolds number of the flow and the aspect ratio of the cavity using complementary numerical simulations and PIV experiments. The clearance of an initial debris cloud is simulated via solutions to an advection-diffusion equation and we characterise the effects of the initial position of the debris cloud within the vortical flow and the Péclet number on clearance time. With only weak diffusion, debris that initiates within closed streamlines can become trapped. We discuss a flow manipulation strategy to extract debris from vortices and decrease washout time.