Grothendieck's Brauer group and the Manin obstruction

In this talk I will outline the two constructions of the Brauer group Br($X$) of a scheme $X$, namely via etale cohomology and Azumaya algebras and briefly describe how one may compute this group using the Hochschild-Serre spectral sequence. In the early '70s Manin observed that one can use the Brauer group of a projective variety $X/k$ to define an obstruction to the existence of rational points on $X$. I will discuss this arithmetic application and time permitting, outline an example for $X$ a K3 surface.