+44 1865 615162
University of Oxford
Andrew Wiles Building
Radcliffe Observatory Quarter
Mathematical modelling of angiogenesis: When a cancer tumour becomes larger than 1-2mm, it requires delivery of nutrients and oxygen to survive. The development of tumour vasculature can be modelled mathematically using a system of equations. I use mathematical and computational techniques to investigate the biological process of angiogenesis, and explore the theoretical effects of anti-angiogenic drug therapies and immunotherapy using ODE and PDE models.
I have worked with my industrial collaborators at Hoffman La Roche in Switzerland to develop a mixed-effects model of angiogenic tumour growth.
I am supervised by Eamonn Gaffney, Helen Byrne and Philip Maini (Wolfson Centre for Mathematical Biology) as well as Jonathan Wagg, Alex Phipps and Benjamin Ribba (Roche).
- DTC 10 week project at the Wolfson Centre for Mathematical Biology and Roche:Angiogenesis Modelling June-August 2013
- DTC 10 week project at the Oxford E-Research Centre and GE Healthcare: Application of Tumour Response Criteria to Novel Tracers August-October 2013
- Completed a short BA Literature Report on The Physics of how Animals Sense Infra-red and Heat , supervised by Dr Stephen Tucker
- Completed a 9 week joint internship at the Saban Research Institute and California Institute of Technology. This included an introduction to laboratory techniques and an extended data-analysis style MRI study.
- Programming: Matlab, C, C++, NONMEM
- Leadership: took part in OUSU Womens' Leadership Programme 2012-13
- Events: Organised Women Inspiring Women symposium March 2013
- Mentoring: Registered mentor under OxFEST mentoring scheme
- Languages: Intermediate German
- Clinical Pharmacology Intern at Genentech, South San Francisco, June-September 2014
- Disease Modelling (Clinical Pharmacology) Intern at Roche, Basel June-December 2015
Roles of Responsibility
- President 2012-2013, Oxford society for Females in Engineering, Science and Technology (OxFEST)
- Student Representative, SABS-IDC 2012-2013
- Lincoln College MCR Social Representative 2013-2014
- Mathematical, Physical and Life Sciences Graduate Division Representative 2014-2015
- Lincoln College MCR President 2014-2015
- Events for Women in Science
- Long distance running
- College tutor for Optimisation Trinity 2015 (First year undergraduates)
- Teaching Assistant for Techniques of Applied Mathematics Michealmas Term 2013 (Third year undergraduates)
- Teaching Assistant for Applied Partial Differential Equations Hilary Term 2014 (Third year undergraduates)
- Demonstrating for Introductory Mathematics at the Doctoral Training Centre. November 2013 and 2014
- Demonstrating for Mathematical Biology at the Doctoral Training Centre. May 2015
- Demonstrating for Systems Medicine at the Doctoral Training Centre. May 2015
- Demonstrating for Mathematical and Computational Biology at the Doctoral Training Centre. May 2015
- Graduate Helper foir STEP/AEA Workshop. January 2014.
- Private Tuition for students aged 7-18
Prizes, Awards, and Scholarships:
Winner of the Short Project Prize 2013 for "A spatially averaged model of angiogenesis". Awarded by the Doctoral Training Centre and sponsored by Microsoft Research, Cambridge.
4 year EPSRC studentship to complete DPhil
Major / Recent Publications:
Hutchinson, L.G., et al., Vascular phenotype identification and anti-angiogenic treatment recommendation: A pseudo-multiscale mathematical model of angiogenesis. J. Theor. Biol. (2016) http://www.sciencedirect.com/science/article/pii/S0022519316001429