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Dr Alexander Fletcher
DPhil, MSc, MA
- Research Fellow in Computational Science
Personal Web Page
eMail:
Alexander [dot] Fletcher [-at-] maths [dot] ox [dot] ac [dot] uk
Contact Form
Phone Number(s):
Reception/Secretary: +44 1865 273525
Direct: +44 1865 283891
Office:
DH43
Departmental Address:
Mathematical Institute
24-29 St Giles'
Oxford
OX1 3LB
England
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Research Interests:
Mathematical biology, individual-based and multiscale modelling, open source software development, with biological applications in development, tissue homeostasis and tumour growth.
Major/Recent Publications:
- I.M.M. van Leeuwen, G.R. Mirams, A. Walter, A.G. Fletcher, P. Murray, J. Osborne, S. Varma, S.J. Young, J. Cooper, J. Pitt-Francis, L. Momtahan, P. Pathmanathan, J.P. Whiteley, S.J. Chapman, D.J. Gavaghan, O.E. Jensen, J.R. King, P.K. Maini, S.L. Waters and H.M. Byrne (2009). An integrative computational model for intestinal tissue renewal. Cell Prolif. 42:617-636.
- J. Pitt-Francis, P. Pathmanathan, M.O. Bernabeu, R. Bordas, J. Cooper, A.G. Fletcher, G.R. Mirams, P. Murray, J.M. Osborne, A. Walter, J. Chapman, A. Garny, I.M.M. van Leeuwen, P.K. Maini, B. Rodriguez, S.L. Waters, J.P. Whiteley, H.M. Byrne and D.J. Gavaghan (2009). Chaste: a test-driven approach to software development for biological modelling. Comput. Phys. Comm., 180:2452-2471.
- P. Pathmanathan, J. Cooper, A.G. Fletcher, G.R. Mirams, L. Momtahan, P. Murray, J. Osborne, J. Pitt-Francis, A. Walter and S.J. Chapman (2009). A computational study of discrete mechanical tissue models. Phys. Biol., 6:036001.
- P. Murray, A. Walter, A.G. Fletcher, C. Edwards, M. Tindall and P.K. Maini (2011). Comparing a discrete and continuum model of the intestinal crypt. Phys. Biol. 8:026011.
- S.-J. Dunn, A.G. Fletcher, S.J. Chapman, D.J. Gavaghan and J.M. Osborne (2012). Modelling the role of the basement membrane in the colonic epithelium. J. Theor. Biol. 298:82-91.
- R. Dello Ioio, C. Galinha, A.G. Fletcher, S.P. Grigg, A. Molnar, S. Sabatini, D. Baulcombe, P.K. Maini and M. Tsiantis (2012). A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis.Curr. Biol. 22:1699-1704.
- G.R. Mirams, C.J. Arthurs, M.O. Bernabeu, R. Bordas, J. Cooper, A. Corrias, Y. Davit, S-J. Dunn,A.G. Fletcher, D.G. Harvey, M.E. Marsh, J.M. Osborne, P. Pathmanathan, J. Pitt-Francis, J. Southern, N. Zemzemi and D.J. Gavaghan (2013). Chaste: an open source C++ library for computational physiology and biology. PLoS Comput. Biol. (in press)
- B. Lloyd-Lewis, A.G. Fletcher, T.C. Dale and H.M. Byrne (2013). Towards a quantitative understanding of the Wnt/β-catenin pathway through simulation and experiment. WIREs Syst. Biol. Med. (in press)
Recent Publications (from MathSciNet):
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MR2972188 Indexed Mirams, Gary R.; Fletcher, Alexander G.; Maini, Philip K.; Byrne, Helen M. A theoretical investigation of the effect of proliferation and adhesion
on monoclonal conversion in the colonic crypt.
J. Theoret. Biol. 312 (2012), 143–156. 92C50
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MR2902900 Indexed Fletcher, Alexander G.; Breward, Christopher J. W.; Chapman, S. Jonathan Mathematical modeling of monoclonal conversion in the colonic
crypt.
J. Theoret. Biol. 300 (2012), 118–133. 92C37
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MR2726233 Indexed Osborne, J. M.; Walter, A.; Kershaw, S. K.; Mirams, G. R.; Fletcher, A. G.; Pathmanathan, P.; Gavaghan, D.; Jensen, O. E.; Maini, P. K.; Byrne, H. M. A hybrid approach to multi-scale modelling of cancer.
With supplementary data available online.
Philos. Trans. R. Soc. Lond. Ser. A Math. Phys. Eng. Sci. 368 (2010), no. 1930, 5013–5028. 92C50
More publications
Teaching:
Stipendiary lecturer in mathematics at St Hugh's college
Lecturer and demonstrator at the LSI, SysBio and SABS IDC Doctoral Training Centres
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