Author
Dritschel, H
Waters, S
Roller, A
Byrne, H
Journal title
Letters in Biomathematics
DOI
10.1080/23737867.2018.1465863
Issue
S1
Volume
5
Last updated
2024-03-27T16:16:29.62+00:00
Page
S36-S68
Abstract
<p>We develop a mathematical model to examine the role of helper and cytotoxic T cells in an anti-tumour immune response. The model comprises three ordinary differential equations describing the dynamics of the tumour cells, the helper, and the cytotoxic T cells and implicitly accounts for immunosuppressive effects. The aim is to investigate how the anti-tumour immune response varies with the level of infiltrating helper and cytotoxic T cells.</p> <br/> <p>Through a combination of analytical studies and numerical simulations, our model exemplifies the three Es of immunoediting: elimination, equilibrium, and escape. Specifically, it reveals that the three Es of immunoediting depend highly on the infiltration rates of the helper and cytotoxic T cells. The model's results indicate that both the helper and cytotoxic T cells play a key role in tumour elimination. They also show that combination therapies that boost the immune system and block tumour-induced immunosuppression may have a synergistic effect in reducing tumour growth.</p>
Symplectic ID
835771
Favourite
Off
Publication type
Journal Article
Publication date
14 May 2018
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