Author
Lewin, T
Maini, P
Moros, E
Enderling, H
Byrne, H
Journal title
Mathematical Modelling of Natural Phenomena
DOI
10.1051/mmnp/2019039
Issue
1
Volume
15
Last updated
2024-04-10T08:50:47.087+01:00
Abstract
In vivo tumours are highly heterogeneous entities which often comprise intratumoural regions of hypoxia and widespread necrosis. In this paper, we develop a new three phase model of nutrient-limited, avascular tumour growth to investigate how dead material within the tumour may influence the tumour’s growth dynamics. We model the tumour as a mixture of tumour cells, dead cellular material and extracellular fluid. The model equations are derived using mass and momentum balances for each phase along with appropriate constitutive equations. The tumour cells are viewed as a viscous fluid pressure, while the extracellular fluid phase is viewed as inviscid. The physical properties of the dead material are intermediate between those of the tumour cells and extracellular fluid, and are characterised by three key parameters. Through numerical simulation of the model equations, we reproduce spatial structures and dynamics typical of those associated with the growth of avascular tumour spheroids. We also characterise novel, non-monotonic behaviours which are driven by the internal dynamics of the dead material within the tumour. Investigations of the parameter sub-space describing the properties of the dead material reveal that the way in which non-viable tumour cells are modelled may significantly influence the qualitative tumour growth dynamics.
Symplectic ID
1053421
Favourite
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Publication type
Journal Article
Publication date
18 Mar 2020
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