L5

to follow

Single-cell sequencing data consists of a point cloud where the points are cells, with coordinates RNA expression levels in each gene. Since the tissue is destroyed by the sequencing procedure, the dynamics of gene expression must be inferred from the structure and geometry of the point cloud. In this talk, we will build a biological interpretation of the one-dimensional cohomology classes in hallmark gene subsets as models for transient biological processes. Such processes include the cell-cycle, but more generally model homeostatic negative feedback loops. Our procedure uses persistent cohomology to identify features, and integration of differential forms to estimate the cascade of genes associated with the underlying dynamics of gene expression.

This is joint work with Markus Youssef and Tâm Nguyen at EPFL.

Periodic point clouds naturally arise when modelling large homogenous structures like crystals. They are naturally attributed with a map to a d-dimensional torus given by the quotient of translational symmetries, however there are many surprisingly subtle problems one encounters when studying their (persistent) homology. It turns out that bisheaves are a useful tool to study periodic data sets, as they unify several different approaches to study such spaces. The theory of bisheaves and persistent local systems was recently introduced by MacPherson and Patel as a method to study data with an attributed map to a manifold through the fibres of this map. The theory allows one to study the data locally, while also naturally being able to appeal to local systems of (co)sheaves to study the global behaviour of this data. It is particularly useful, as it permits a persistence theory which generalises the notion of persistent homology. In this talk I will present recent work on the theory and implementation of bisheaves and local systems to study 1-periodic simplicial complexes. Finally, I will outline current work on generalising this theory to study more general periodic systems for d-periodic simplicial complexes for d>1. 

To neural activity one may associate a space of correlations and a space of population vectors. These can provide complementary information. Assume the goal is to infer properties of a covariate space, represented by ochestrated activity of the recorded neurons. Then the correlation space is better suited if multiple neural modules are present, while the population vector space is preferable if neurons have non-convex receptive fields. In this talk I will explain how to coherently combine both pieces of information in a bifiltration using Dowker complexes and their total weights. The construction motivates an interesting extension of Dowker’s duality theorem to simplicial categories associated with two composable relations, I will explain the basic idea behind it’s proof.

The natural occurrence of singular spaces in applications has led to recent investigations on performing topological data analysis (TDA) on singular data sets. However, unlike in the non-singular scenario, the homotopy type (and consequently homology) are rather course invariants of singular spaces, even in low dimension. This suggests the use of finer invariants of singular spaces for TDA, making use of stratified homotopy theory instead of classical homotopy theory.
After an introduction to stratified homotopy theory, I will describe the construction of a persistent stratified homotopy type obtained from a sample with two strata. This construction behaves much like its non-stratified counterpart (the Cech complex) and exhibits many properties (such as stability, and inference results) necessary for an application in TDA.
Since the persistent stratified homotopy type relies on an already stratified point-cloud, I will also discuss the question of stratification learning and present a convergence result which allows one to approximately recover the stratifications of a larger class of two-strata stratified spaces from sufficiently close non-stratified samples. In total, these results combine to a sampling theorem guaranteeing the (approximate) inference of (persistent) stratified homotopy types from non-stratified samples for many examples of stratified spaces arising from geometrical scenarios.

The simplicial volume of a simplicial complex is a topological invariant
related to the growth of the fundamental group, which gives rise to a
semi-norm in homology. In this talk, we introduce the volume entropy
semi-norm, which is also related to the growth of the fundamental group
of simplicial complexes and shares functorial properties with the
simplicial volume. Answering a question of Gromov, we prove that the
volume entropy semi-norm is equivalent to the simplicial volume
semi-norm in every dimension. Joint work with I. Babenko.