Mathematical Biology and Ecology Seminar

The development of a complex functional multicellular organism from a single cell involves tightly regulated and coordinated cell behaviours coupled through short- and long-range biochemical and mechanical signals. To truly comprehend this complexity, alongside experimental approaches we need mathematical and computational models, which can link observations to mechanisms in a quantitative, predictive, and experimentally verifiable way. In this talk I will describe our efforts to model aspects of embryonic development, focusing in particular on the planar polarised behaviours of cells in epithelial tissues, and discuss the mathematical and computational challenges associated with this work. I will also highlight some of our work to improve the reproducibility and re-use of such models through the ongoing development of Chaste (https://github.com/chaste), an open-source C++ library for multiscale modelling of biological tissues and cell populations.

Microbial communities contain many evolving and interacting bacteria, which makes them complex systems that are difficult to understand and predict. We use theory – including game theory, agent-based modelling, ecological network theory and metabolic modelling - and combine this with experimental work to understand what it takes for bacteria to succeed in diverse communities. One way is to actively kill and inhibit competitors and we study the strategies that bacteria use in toxin-mediated warfare. We are now also using our approaches to understand the human gut microbiome and its key properties including ecological stability and the ability to resist invasion by pathogens (colonization resistance). Our ultimate goal is to both stabilise microbiome communities and remove problem species without the use of antibiotics.

Blood vessels are among the most vital structures in the human body, forming intricate networks that connect and support various organ systems. Remarkably, during early embryonic development—before any blood vessels are visible—their precursor cells are arranged in stereotypical patterns throughout the embryo. We hypothesize that these patterns guide the directional growth and fusion of precursor cells into hollow tubes formed from initially solid clusters. Further analysis of cells within these clusters reveals unique organization that may influence their differentiation into endothelial and blood cells. In this work, I revisit the problem of pattern formation through the lens of active matter physics, using both developing embryonic systems and in vitro cell culture models where similar patterns are observed during tissue budding. These different systems exhibit similar patterning behavior, driven by changes in cellular activity, adhesion and motility.