to follow

to follow

It is known for a long time, due to a celebrated theorem of Ornstein and Weiss, that (classical/plain) orbit equivalence offers no information about ergodic probability measure preserving actions of amenable groups. On the other hand, conjugacy is too intractable, and effectively hopeless to study in full generality. Quantitative orbit equivalence aims to bridge this gap by adding intermediate layers of rigidity— a strategy that has borne fruit already in the late 1960s but was used as a general framework only semi-recently. In this talk, Spyridon Petrakos will introduce aspects of quantitative orbit equivalence and present a complete picture of it for integer odometers. This is joint work with Petr Naryshkin.

TBA 

TBA

Heterogeneity is a fundamental feature of biological systems. Oncology is one of the fields in which this feature is most evident, as its key players are characterised by mutability, plasticity, and often “uncontrolled” dynamics. Whether heterogeneity arises from spatial structure, environmental variability, or cellular traits, effective therapeutic strategies must explicitly account for it in order to eradicate or control tumours.

From a modern perspective, this requires balancing the hit-hard / keep-it-sensitive trade-off, while also considering not only medical but also broader patient-related side effects of treatments. Contemporary medicine is increasingly exploring ways to exploit the very characteristics that have historically made cancer so dangerous, turning them into potential advantages for therapy.

The multiscale nature of tumour systems, together with the need to predict the combined effects of multiple, non-parallelisable processes, makes the development of optimised mathematical tools particularly compelling. Such tools can address questions that are both scientifically challenging and highly relevant from a clinical and humanitarian perspective.

In this seminar, we will analyse tumour masses from a structured population perspective, focusing on the role of heterogeneity in shaping therapeutic strategies. We will first discuss how heterogeneity in phenotypic composition and nutrient distribution influences the eco-evolutionary dynamics of tumour growth. We will then consider more specifically its impact on radiotherapy.

In particular, we will highlight the advantages of mathematically rigorous modelling in bridging theory and biology. We will also adopt a more exploratory perspective, using these models to illustrate how mathematics can serve as a potential decision-support tool for the selection and optimisation of treatment protocols, within an image- and model-driven framework.

The final part of the seminar will focus on potential future developments, with the aim of fostering an open and collaborative discussion on novel perspectives to improve understanding, prediction, and therapeutic optimisation.

TBA

TBA

TBA

to follow

Professor Luis Nunes Vicente will talk about 'Reducing Sample Complexity in Stochastic Derivative-Free Optimization via Tail Bounds and Hypothesis Testing';

We introduce and analyze new probabilistic strategies for enforcing sufficient decrease conditions in stochastic derivative-free optimization, with the goal of reducing sample complexity and simplifying convergence analysis. First, we develop a new tail bound condition imposed on the estimated reduction in function value, which permits flexible selection of the power used in the sufficient decrease test, q in (1,2]. This approach allows us to reduce the number of samples per iteration from the standard O(delta^{−4}) to O(delta^{-2q}), assuming that the noise moment of order q/(q-1) is bounded. Second, we formulate the sufficient decrease condition as a sequential hypothesis testing problem, in which the algorithm adaptively collects samples until the evidence suffices to accept or reject a candidate step. This test provides statistical guarantees on decision errors and can further reduce the required sample size, particularly in the Gaussian noise setting, where it can approach O(delta^{−2-r}) when the decrease is of the order of delta^r. We incorporate both techniques into stochastic direct-search and trust-region methods for potentially non-smooth, noisy objective functions, and establish their global convergence rates and properties. 

This is joint work with Anjie Ding, Francesco Rinaldi, and Damiano Zeffiro.

TBA

Many cells exhibit exponential growth not only at the population level but also at the single-cell level. However, single-cell growth rates fluctuate over time. We distinguish between two conceptually distinct sources of growth rate fluctuations: intrinsic continuous fluctuations resulting from intracellular processes, and fluctuations that originate at division events, which we refer to as kicks. We use a simple model to describe single-cell growth and identify the signatures of continuous noise and division kicks. To infer the true biological behavior reliably from experiments, it is crucial to account for measurement noise. We derive analytical expressions for the statistics of meaningful observables, accounting for continuous fluctuations, division kicks, and measurement noise. Importantly, we find that ignoring measurement noise can lead to incorrect biological conclusions. Our results provide insights into how different sources of growth rate variability and measurement errors influence observed cell size dynamics, offering an interpretable framework for analyzing experimental data in cellular biology. 

TBA

TBA

TBA

to follow

In the context of Fourier analysis on the real line, a \textit{one-sided problem} involves deducing properties of a function $f$ from some information about the restriction of its Fourier transform $\widehat{f}$ to a half-line, for instance to $\mathbb{R}_- := (-\infty, 0)$. A prototypical result, which is foundational to the theory of Hardy spaces on $\mathbb{R}$, asserts that if $f \in L^2(\mathbb{R})$ is non-zero and $\widehat{f}$ vanishes on a half-line, then $f$ satisfies the \textit{Szeg\H{o} condition} $\int_{-\infty}^\infty \frac{\log |f(x)|}{1+x^2} \, dx > -\infty$. 

Various problems in operator theory involve the study of functions $f$ satisfying a weaker condition of decay of $\widehat{f}$ on a half-line. In this setting, simple examples show that the Szeg\H{o} condition need not be satisfied. However, the following local Szeg\H{o}-type conditions hold: if the decay of $\widehat{f}$ is strong enough on a half-line, then the mass of the function $f \in L^2(\mathbb{R})$ must concentrate enough for the integral $\int_E \log |f(x)| dx$ to converge on a "massive" set $E$. 

In his talk, Bartosz Malman will describe this mass condensation phenomenon and its applications to operator-theoretic problems.

tbc

TBA

Mechanistic ordinary differential equation (ODE) models are a powerful tool to study dynamic biological systems. However, their predictive power is constrained by gaps, biases, and inconsistencies in the literature. They typically also require quantitative time-lapse data for training, which is time-consuming to collect. At the same time, machine-learning approaches can capture complex patterns from data, but they are often harder to interpret and typically require large training datasets. Hybrid scientific machine learning (SciML) models offer a promising way to combine the strengths of both approaches by integrating mechanistic models with flexible data-driven modules. 
Despite this promise, the use of SciML in biology remains limited by insufficient infrastructure. Dedicated software is needed because coding end-to-end differentiable workflows for gradient-based training of hybrid models is technically challenging. In addition, model exchange is hindered by the lack of a standardized, reproducible format for specifying SciML training problems, analogous to the PEtab standard for ODE models. To address these challenges, we developed PEtab-SciML, an extension of the PEtab format, and implemented support for it in the state-of-the-art modeling toolboxes PEtab.jl and AMICI. In this seminar, I will introduce the PEtab-SciML format. Using real-data examples, I will show how PEtab-SciML enables the integration of diverse data modalities into dynamic model training; such as learning the kinetic parameters of an ODE model from omics and protein sequence data. I will also show how it supports machine-learning-based black-boxing of complex model components, such as quarantine strength in an SIR model. Finally, I will show how PEtab-SciML enables the use of efficient training strategies, such as curriculum learning, that make SciML models easier to train and apply in practice. 

TBA

In this talk, we focus on the existence of time-periodic leapfrogging vortex rings for the three-dimensional incompressible Euler equations, thereby providing a rigorous realization of a phenomenon first conjectured by Helmholtz (1858). In the leapfrogging motion, two coaxial vortex rings periodically exchange positions, a striking behavior repeatedly observed in experiments and numerical simulations, yet lacking complete mathematical justification. Our construction relies on a desingularization of two interacting vortex filaments within the contour dynamics formulation, which yields a Hamiltonian description of nearly concentric vortex rings. The main difficulty stems from a singular small-divisor problem arising in the linearized transport dynamics, where the effective time scale degenerates with the ring thickness parameter. To overcome this obstruction, we develop a degenerate KAM-type analysis combined with pseudo-differential operator techniques to control the linearized dynamics around symmetric configurations. Combining these tools with a Nash-Moser iteration scheme, we construct families of nontrivial time-periodic solutions in an almost uniformly translating frame. This establishes the first rigorous construction of classical leapfrogging motion for axisymmetric Euler flows without swirl, with no restriction on the time interval of existence. 

This is a joint work with Zineb Hassainia and Taoufik Hmidi.

to follow

The boundedness of Fourier multipliers on non-commutative $L_p$-spaces ($1 < p < \infty$) is a fundamental problem in non-commutative analysis. Building on the non-commutative Cotlar identity introduced by Mei and Ricard (2017), which yields $L_p$-boundedness ($1 < p < \infty$) of Hilbert transforms on amalgamated free products of finite von Neumann algebras, their approach relies heavily on freeness in the underlying free product structure.

In this talk, Xiaoqi Lu introduces a new strategy that overcomes this limitation. Our approach combines a generalized Cotlar identity, which holds on suitable subspaces and captures non-freeness information, with an additional condition related to the property of Rapid Decay to control the remaining components. From this framework, we establish the $L_p$-boundedness ($1 < p < \infty$) of Rademacher-type Hilbert transforms on graph products of finite von Neumann algebras. This unified framework extends earlier results for free products of finite von Neumann algebras and for graph products of groups acting on right-angled buildings. This is a joint work with Runlian Xia.

Dr Lindon Roberts will talk about: 'Optimization Algorithms for Bilevel Learning with Applications to Imaging'

Many imaging problems, such as denoising or inpainting, can be expressed as variational regularization problems. These are optimization problems for which many suitable algorithms exist. We consider the problem of learning suitable regularizers for imaging problems from example (training) data, which can be formulated as a large-scale bilevel optimization problem. 

In this talk, I will introduce new deterministic and stochastic algorithms for bilevel optimization, which require no or minimal hyperparameter tuning while retaining convergence guarantees. 

This is joint work with Mohammad Sadegh Salehi and Matthias Ehrhardt (University of Bath), and Subhadip Mukherjee (IIT Kharagpur).

TBA

TBA

TBA