Interpreting non-invasive measurement of markers of diseases including diabetes and Alzheimer’s

15 December 2017

Lein Applied Diagnostics has a novel optical measurement technique that is used to measure various parameters in the body for medical applications.

Two particular areas of interest are non-invasive glucose measurement for diabetes care and the diagnosis of diabetes. Both measurements are based on the eye and involve collecting complex data sets and modelling their links to the desired parameter.

If we take non-invasive glucose measurement as an example, we have two data sets – that from the eye and the gold standard blood glucose reading. The goal is to take the eye data and create a model that enables the calculation of the glucose level from just that eye data (and a calibration parameter for the individual). The eye data consists of measurements of apparent corneal thickness, anterior chamber depth, optical axis orientation; all things that are altered by the change in refractive index caused by a change in glucose level. So, they all correlate with changes in glucose as required but there are also noise factors as these parameters also change with alignment to the meter etc. The goal is to get to a model that gives us the information we need but also uses the additional parameter data to discount the noise features and thereby improve the accuracy.

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