Mathematical models for the effect of anti-vascular endothelial growth factor on visual acuity.

Author: 

Edwards, D
Emerick, B
Kondic, A
Kiradjiev, K
Raymond, C
Zyskin, M

Publication Date: 

24 September 2020

Journal: 

Journal of mathematical biology

Last Updated: 

2020-10-28T17:52:59.717+00:00

DOI: 

10.1007/s00285-020-01544-4

abstract: 

The standard of care treatment for neovascular age-related macular degeneration, delivered as ocular injection, is based on anti-vascular endothelial growth factor (anti-VEGF). The course of treatment may need to be modified quickly for certain patients based on their response. Models that track both the concentration and the response to an anti-VEGF treatment are presented. The specific focus is to assess the existence of analytical solutions for the different types of models. Both an ODE-based model and a map-based model illustrate the dependence of the solution on various biological parameters and allow the measurement of patient-specific parameters from experimental data. A PDE-based model incorporates diffusive effects. The results are consistent with observed values, and could provide a framework for practitioners to understand the effect of the therapy on the progression of the disease in both responsive and non-responsive patients.

Symplectic id: 

1134971

Submitted to ORA: 

Not Submitted

Publication Type: 

Journal Article