Factorization algebras in quite a lot of generality

The objects of arithmetic geometry are not manifolds. Some concepts from differential geometry admit analogues in arithmetic, but they are not straightforward. Nevertheless, there is a growing sense that the right way to understand certain Langlands phenomena is to study quantum field theories on these objects. What hope is there of making this thought precise? I will propose the beginnings of a mathematical framework via a general theory of factorization algebras. A new feature is a subtle piece of additional structure on our objects – what I call an _isolability structure_ – that is ordinarily left implicit.