The topology of the moduli space of stable bundles (of coprime rank and degree) on a smooth curve can be understood from different points of view. Atiyah and Bott calculated the Betti numbers by gauge-theoretic methods (using equivariant Morse theory for the Yang-Mills functional), arriving at the same inductive formula which had been obtained previously by Harder and Narasimhan using arithmetic techniques. An intermediate interpretation (algebro-geometric in nature but dealing with infinite-dimensional parameter spaces as in the gauge theory picture) comes from thinking about vector bundles in terms of matrix divisors, generalising the Abel-Jacobi map to higher rank bundles.
I'll sketch these different approaches, emphasising their parallels, and in the end I'll speculate about how (some of) these methods could be made to work when the underlying curve acquires nodal singularities.