An integral part of the brain is a fluid flow system that is separate from brain tissue and the cerebral blood flow system: cerebrospinal fluid (CSF) is produced near the centre of the brain, flows out and around the brain, including around the spinal cord and is absorbed primarily in a region between the brain tissue and the skull. Hydrocephalus covers a broad range of anomalous flow and pressure situations: the normal flow path can become blocked, other problems can occur which result in abnormal tissue deformation or pressure changes. This talk will describe work that treats brain tissue as a poroelastic matrix through which the CSF can move when normal flow paths are blocked, producing tissue deformation and pressure changes. We have a number of models, the simplest treating the brain and CSF flow as having spherial symmetry ranging to more complex, fully three-dimensional computations. As well as considering acute hydrocephalus, we touch on normal pressure hydrocephalus, idiopathic intracranial hypertension and simulation of an infusion test. The numerical methods used are a combination of finite difference and finite element techniques applied to an interesting set of hydro-elastic equations.
