The Calogero-Painlevé systems were introduced in 2001 by K. Takasaki as a natural generalization of the classical Painlevé equations to the case of the several Painlevé “particles” coupled via the Calogero type interactions. In 2014, I. Rumanov discovered a remarkable fact that a particular case of the Calogero– Painlevé II equation describes the Tracy-Widom distribution function for the general $\beta$-ensembles with the even values of parameter $\beta$. in 2017 work of M. Bertola, M. Cafasso , and V. Rubtsov, it was proven that all Calogero-Painlevé systems are Lax integrable, and hence their solutions admit a Riemann-Hilbert representation. This important observation has opened the door to rigorous asymptotic analysis of the Calogero-Painlevé equations which in turn yields the possibility of rigorous evaluation of the asymptotic behavior of the Tracy-Widom distributions for the values of $\beta$ beyond the classical $\beta =1, 2, 4$. In the talk these recent developments will be outlined with a special focus on the Calogero-Painlevé system corresponding to $\beta = 6$. This is a joint work with Andrei Prokhorov.