Department of Engineering Science, University of Oxford

When the human eye looks at a distant object, the lens is held in a state of tension by a set of fibres (known as zonules) that connect the lens to the ciliary body. To view a nearby object, the ciliary muscle (which is part of the ciliary body) contracts. This reduces the tension in the zonules, the lens assumes a thicker and more rounded shape and the optical power of the eye increases.

This process is known as accommodation.

With increased age, however, the accommodation mechanism becomes increasingly ineffective so that, from an age of about 50 years onwards, it effectively ceases to function. This condition is known as presbyopia. There is considerable interest in the ophthalmic community on developing a better understanding of the ageing processes that cause presbyopia. As well as being an interesting scientific question in its own right, it is hoped that this improved understanding will lead to improved surgical procedures (e.g. to re-start the accommodation process in elderly cataract patients).

Inverse problems arise with regularity (sic!) in the context of our study of the deformation of solids, and its characterisation (in terms of diffraction and imaging) using radiation (neutrons and X-rays).

I wish to introduce several examples where the advancement of inverse problem methods can make a significant impact on applicatins.

1. Inverse eigenstrain analysis of residual stress states

2. Strain tomography

3. Strain image correlation

Depending on the time available, I may also mention (a) Rietveld refinement of diffraction patterns from polycrystalline aggregates, and
(b) Laue pattern indexing and energy dispersive detection for single grain strain analysis.