Dept of Chemistry University of Oxford

Simulating the long time and length scales associated with DNA self-assembly
and DNA nanotechnology is not currently feasible with models at an atomic level
of detail. We, therefore, developed oxDNA a coarse-grained representation of
DNA that aims to capture the fundamental structural, thermodynamic and
mechanical properties of double-stranded and single-stranded DNA, which we have
subsequently applied to study a wide variety of DNA biophysical properties and
DNA nanotechnological systems.