DAMTP University of Cambridge

The morphogenesis of branched tissues has been a subject of long-standing interest and debate. Although much is known about the signaling pathways that control cell fate decisions, it remains unclear how macroscopic features of branched organs, including their size, network topology and spatial patterning, are encoded. Based on large-scale reconstructions of the mouse mammary gland and kidney, we show that statistical features of the developing branched epithelium can be explained quantitatively by a local self-organizing principle based on a branching and annihilating random walk (BARW). In this model, renewing tip-localized progenitors drive a serial process of ductal elongation and stochastic tip bifurcation that terminates when active tips encounter maturing ducts. Finally, based on reconstructions of the developing mouse salivary gland, we propose a generalisation of BARW model in which tips arrested through steric interaction with proximate ducts reactivate their branching programme as constraints become alleviated through the expansion of the underlying matrix. This inflationary branching-arresting random walk model presents a general paradigm for branching morphogenesis when the ductal epithelium grows cooperatively with the matrix into which it expands.

Ice streams are fast flowing regions of ice that generally slide over a layer of unconsolidated, water-saturated subglacial sediment known as till.  A striking feature that has been observed geophysically is that subglacial till has been found to accumulate distinctively into sedimentary wedges at the grounding zones (regions where ice sheets begin to detach from the bedrock to form freely floating ice shelves) of both past and present-day ice sheets. These grounding-zone wedges have important implications for ice-sheet stability against grounding zone retreat in response to rising sea levels, and their origins have remained a long-standing question. Using a combination of mathematical modelling, a series of laboratory experiments, field data and numerical simulations, we develop a fluid-mechanical model that explains the mechanism of the formation of these sedimentary wedges in terms of the loading and unloading of deformable till in three dynamical regimes. We also undertake a series of analogue laboratory experiments, which reveal that a similar wedge of underlying fluid accumulates spontaneously in experimental grounding zones, we formulate local conditions relating wedge slopes in each of the scenarios and compare them to available geophysical radargram data at the well lubricated, fast-flowing Whillans Ice Stream.

This will be a whistle-stop tour of a few topics on infectious disease modelling, mainly influenza. Topics to include:

• challenges in capturing dynamics of pathogens with multiple co-circulating strains
• untangling the 2009 influenza pandemic from medical insurance claims data from the US
• bioinformatic methods to detect viral packaging signals
• and a big science project (top secret until the talk!)

Julia will be visiting the Mathematical Institute on sabbatical this term, and hopes this talk will help us find areas of overlapping interests.