Dept of Mathematics University of Surrey

The role of tissue stiffness in controlling cell behaviours ranging from proliferation to signalling and activation is by now well accepted. A key focus of experimental studies into mechanotransduction are focal adhesions, localised patches of strong adhesion, where cell signalling has been established to occur. However, these adhesion sites themselves alter the mechanical equilibrium of the system determining the force balance and work done. To explore this I have developed an active matter continuum description of cellular contractility and will discuss recent results on the specific role of spatial positioning of adhesions in mechanotransduction. I show using energy arguments why the experimentally observed arrangements of focal adhesions develop and the implications this has for stiffness sensing and cellular contractility control. I will also show how adhesions play distinct roles in single cells and tissue layers respectively drawing on recent experimental work with Dr JR Davis (Manchester University) and Dr Nic Tapon (Crick Institute) with applications to epithelial layers and organoids.

After a review of Batalin-Vilkovisky formalism and homotopy algebras, we discuss how these structures emerge in quantum field theory and gravity. We focus then on the application of these sophisticated mathematical tools to scattering amplitudes (both tree- and loop-level) and to the understanding of the dualities between gauge theories and gravity, highlighting generalizations of old results and presenting new ones.

I will discuss some properties of delay differential equations in which the delay is not prescribed a-priori but is determined from a threshold condition. Sometimes the delay depends on the solution of the differential equation and its history. A scenario giving rise to a threshold type delay is that larval insects sometimes experience halting or slowing down of development, known as diapause, perhaps as a consequence of intra-specific competition among larvae at higher densities. Threshold delays can result in population dynamical models having some unusual properties, for example, if the model has an Allee effect then diapause may cause extinction in some parameter regimes even where the initial population is high.

Please  note that this talk is only suitable for Mathematicians.

The ability of cells to sense and respond to the mechanical properties of their environments is fundamental to cellular behaviour, with stiffness found to be a key control parameter. The physical mechanisms underpinning mechanosensing are, however, not well understood. I here consider the key physical cellular behaviours of active contractility of the internal cytoskeleton and cell growth, coupling these into mechanical models. These models suggest new distinct mechanisms of mechanotransduction in cells and tissues.