(Dept of Physical and Biological Engineering Princeton University

We aim to establish and experimentally test mathematical models of embryogenesis. While the foundation of this research is based on models of isolated developmental events, the ultimate challenge is to formulate and understand dynamical systems encompassing multiple stages of development and multiple levels of regulation. These range from specific chemical reactions in single cells to coordinated dynamics of multiple cells during morphogenesis. Examples of our dynamical systems models of embryogenesis – from the events in the Drosophila egg to the early stages of gastrulation – will be presented. Each of these will demonstrate what had been learned from model analysis and model-driven experiments, and what further research directions are guided by these models.