Mathematical modelling of abnormal beta oscillations in Parkinson’s disease

20 February 2014
In Parkinson’s disease, increased power of oscillations in firing rate has been observed throughout the cortico-basal-ganglia circuit. In particular, the excessive oscillations in the beta range (13-30Hz) have been shown to be associated with difficulty of movement initiation. However, on the basis of experimental data alone it is difficult to determine where these oscillations are generated, due to complex and recurrent structure of the cortico-basal-ganglia-thalamic circuit. This talk will describe a mathematical model of a subset of basal-ganglia that is able to reproduce experimentally observed patterns of activity. The analysis of the model suggests where and under which conditions the beta oscillations are produced.
  • Industrial and Applied Mathematics Seminar