Technological breakthroughs in comprehensive survey of cell phenotypes – can the analytical tools catch up?".

26 May 2017
14:00
Professor Irena Udalova QBIOX Colloquium
Abstract

The ability to study the transcriptome, proteome – and other aspects – of many individual cells represents one of the most important technical breakthroughs and tools in biology and medical science of the past few years. They are revolutionising study of biological systems and human disease, enabling for example: hypothesis-free identification of rare pathogenic (or protective) cell subsets in chronic diseases, routine monitoring of patient immune phenotypes and direct discovery of mole cular targets in rare cell populations. In parallel, new computational and analytical approaches are being intensively developed to analyse the vast data sets generated by these technologies. However, there is still a huge gap between our ability to generate the data, analyse their technical soundness and actually interpret them. The QBIOX network may provide for a unique opportunity to complement recent investments in Oxford technical capabilities in single-cell technologies with the development of revolutionary, visionary ways of interpreting the data that would help Oxford researchers to compete as leaders in this field.

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