Global well-posedness of 3D Navier-Stokes equations (NSEs) is one of the biggest open problems in modern mathematics. A long-standing conjecture in stochastic fluid dynamics suggests that physically motivated noise can prevent (potential) blow-up of solutions of the 3D NSEs. This phenomenon is often referred to as `regularization by noise'. In this talk, I will review recent developments on the topic and discuss the solution to this problem in the case of the 3D NSEs with small hyperviscosity, for which the global well-posedness in the deterministic setting remains as open as for the 3D NSEs. An extension of our techniques to the case without hyperviscosity poses new challenges at the intersection of harmonic and stochastic analysis, which, if time permits, will be discussed at the end of the talk.