Alois Alzheimer called Alzheimer's disease (AD) the disease of forgetfulness in a 1906 lecture that would later mark its discovery. Alzheimer noticed the presence of aggregated protein plaques, made up of misfolded variants of amyloid-beta (A$\beta$) and tau ($\tau$P) proteins, in the brain of one of his patients. These plaques are thought to be the drivers of the overall cognitive decline that is observed in AD. AD is now one of the leading causes of death in many developed countries, including the United Kingdom.

In quantum many body physics, we look for universal features that allow us to classify complex quantum systems. This classification leads to phase diagrams of quantum systems. These are analogous to the familiar phase diagram of water at different temperatures and pressures, with ice and vapour constituting two phases. Quantum phase diagrams correspond to the different phases of matter at zero temperature, where the system is in its lowest energy state (usually called the ground state).

Oxford Mathematicians Samuel N. Cohen, Christoph Reisinger and Sheng Wang have developed new methods to help machine learning build economically reasonable models for options markets. By embedding no-arbitrage restrictions within a neural network, more trustworthy and realistic models can be built, allowing for better risk management in the banking system.

In the 1680s there was a coffee house in London by the name of "Lloyd's". This place, catering to early maritime insurers, lent its name to the nascent English insurance market place, the now famous Lloyd's of London.

As we have seen over the past year, the ability to accurately predict the course of an epidemic is imperative when making decisions about how to control the spread of a virus.

Tissue oxygenation plays a crucial role in the growth of cancerous tumours and their response to treatments. While it may seem intuitive that reducing oxygen delivery to a tumour would be a treatment therapy, low oxygen levels (hypoxia) can significantly reduce the effectiveness of treatments such as radiotherapy and some chemotherapies. Therefore, understanding the dynamics of a tumour's red blood cells - which carry oxygen through the vasculature - is of vital importance.

One of the great puzzles of the current COVID-19 crisis is the observation that older people have a much higher risk of becoming seriously ill. While it is usually commonly accepted that the immune system fails progressively with age, the actual mechanism leading to this effect was not fully understood. In a recent work, Sam Palmer from Oxford Mathematics and his colleagues in Cambridge have proposed a simple and elegant solution to this puzzle.

How do we design face masks that efficiently remove contaminants while ensuring that we can still breathe easily? One complicating factor with this question is the fact that the properties of the material that we start off with for our face mask can be very different when in use. A key example is seen when you stretch the mask around your face to put it on. In doing so, you also stretch the pores, i.e., the holes in the material that allow the air to pass through.

The International Congress of Mathematicians (ICM) that was held in Oslo in July 1936 was a unique event that took place in turbulent times, research by Oxford Mathematician Christopher Hollings has revealed.

Oxford Mathematician Aymeric Vie, first year DPhil student at the Centre for Doctoral Training, Mathematics of Random Systems, describes his work on the population network structure of genetic algorithms.This work identifies new ways to improve the performance of those stochastic algorithms, and has received a Best Paper Award at the Genetic and Evolutionary Computat

Oxford Mathematicians and Economists Maria del Rio-Chanona, Penny Mealy, Mariano Beguerisse-Díaz, François Lafond, and J. Doyne Farmer discuss their network model of labor market dynamics.

By pooling resources between cells, colonies of bacteria can exhibit behaviours far beyond the capabilities of an individual bacterium. For example, bacterial populations can encase themselves in a self-generated polymer matrix that shelters cells in the core of the population from the external environment. Such communities are termed “bacterial biofilms”, and show increased tolerance to antimicrobial treatments such as antibiotics.

Social distancing is integral to our lives these days, but distancing also underpins the ordered patterns and arrangements we see all around us in Nature. Oxford Mathematician Priya Subramanian studies the defects in such patterns and shows how they relate to the underlying pattern, i.e. to the distancing itself.

When Oxford Mathematician Alain Goriely was approached by his collaborator Ellen Kuhl from Stanford University to work on a travel restriction issue in Newfoundland he started a Coronavirus journey that ended up in the Canadian Supreme Court.

Mathematical models have been used throughout the COVID-19 pandemic to help plan public health measures. Attention is now turning to how interventions can be removed while continuing to restrict transmission. Predicting the effects of different possible COVID-19 exit strategies is an important current challenge requiring mathematical modelling, but many uncertainties remain.

Oxford Mathematician Katherine Staden talks about the mathematics of seating plans.

The Coronavirus disease pandemic (COVID-19) poses unprecedented challenges for governments and societies around the world. In addition to medical measures, non-pharmaceutical measures have proven to be critical for delaying and containing the spread of the virus. However, effective and rapid decision-making during all stages of the pandemic requires reliable and timely data not only about infections, but also about human behaviour, especially on mobility and physical co-presence of people.