Fri, 11 Jun 2010

12:30 - 13:30
Gibson 1st Floor SR

Homogenization approximation for PDEs with non-separated scales

Lei Zhang
(Hausdorff Center for Mathematics)
Abstract

Numerical homogenization/upscaling for problems with multiple scales have attracted increasing attention in recent years. In particular, problems with non-separable scales pose a great challenge to mathematical analysis and simulation.

In this talk, we present some rigorous results on homogenization of divergence form scalar and vectorial elliptic equations with $L^\infty$ rough coefficients which allow for a continuum of scales. The first approach is based on a new type of compensation phenomena for scalar elliptic equations using the so-called ``harmonic coordinates''. The second approach, the so-called ``flux norm approach'' can be applied to finite dimensional homogenization approximations of both scalar and vectorial problems with non-separated scales. It can be shown that in the flux norm, the error associated with approximating the set of solutions of the PDEs with rough coefficients, in a properly defined finite-dimensional basis, is equal to the error associated with approximating the set of solutions of the same type of PDEs with smooth coefficients in a standard finite element space. We will also talk about the ongoing work on the localization of the basis in the flux norm approach.

Fri, 11 Jun 2010

11:30 - 13:00
OCCAM Common Room (RI2.28)

OCCAM group meeting

Various
(Oxford)
Fri, 11 Jun 2010
09:00
L3

2-Dimensional Algebra and 3-Dimensional Local Field Theory

Chris Douglas
Abstract

Witten showed that the Jones polynomial invariants of knots can be computed in terms of partition functions of a (2+1)-dimensional topological field theory, namely the SU(2) Chern-Simons theory. Reshetikhin and Turaev showed that this theory extends to a (1+1+1)-dimensional topological field theory---that is, there is a Chern-Simons-type invariant associated to 3-manifolds, 3-manifolds with boundary, and 3-manifolds with codimension-2 corners.

I will explain the notion of a local or (0+1+1+1)-dimensionaltopological field theory,  which has, in addition to the structure of a (1+1+1)-dimensional theory, invariants associated to 3-manifolds with codimension-3 corners.  I will describe a notion of 2-dimensional algebra that allows us to construct and investigate such local field theories.  Along the way I will discuss the geometric classification of local field theories, and explain the dichotomy between categorification and algebraification.

 

These talks are based on joint work with Arthur Bartels and Andre Henriques.
Thu, 10 Jun 2010
17:00
L3

Simplicity of certain automorphism groups

Katrin Tent
(Muenster)
Abstract

Simple groups of Lie type have a purely group theoretic characterization in terms of subgroup configurations. We here show that for certain Fraisse limits, the automorphism group is a simple group.

Thu, 10 Jun 2010

13:00 - 18:00

OxPDE lunchtime seminar and Keble Workshop on PDE

Walter Craig, Mikhail Feldman, John M. Ball, Apala Majumdar, Robert Pego
Abstract

{\bf Keble Workshop on Partial Differential Equations

in Science and Engineering}

\\

\\Place: Roy Griffiths Room in the ARCO Building, Keble College

\\Time: 1:00pm-5:10pm, Thursday, June 10.

\\

\\

Program:\\

\\ 1:00-1:20pm: Coffee and Tea

\\

\\ 1:20-2:10pm: Prof. Walter Craig (Joint with OxPDE Lunchtime Seminar)

\\

\\ 2:20-2:40pm Prof. Mikhail Feldman

\\

\\ 2:50-3:10pm Prof. Paul Taylor

\\

\\ 3:20-3:40pm Coffee and Biscuits

\\

\\ 3:40-4:00pm: Prof. Sir John Ball

\\

\\ 4:10-4:30pm: Dr. Apala Majumdar

\\

\\ 4:40-5:00pm: Prof. Robert Pego

\\

\\ 5:10-6:00pm: Free Discussion

\\

\\{\bf Titles and Abstracts:}

\\

1.{\bf Title: On the singular set of the Navier-Stokes equations

\\ Speaker: Prof. Walter Craig, McMaster University, Canada}

\\ Abstract:\\

The Navier-Stokes equations are important in

fluid dynamics, and a famous mathematics problem is the

question as to whether solutions can form singularities.

I will describe these equations and this problem, present

three inequalities that have some implications as to the

question of singularity formation, and finally, give a

new result which is a lower bound on the size of the

singular set, if indeed singularities exist.

\\

\\{\bf 2. Title: Shock Analysis and Nonlinear Partial Differential Equations of Mixed Type.

\\ Speaker: Prof. Mikhail Feldman, University of Wisconsin-Madison, USA}

\\

\\ Abstract:\\ Shocks in gas or compressible fluid arise in various physical

situations, and often exhibit complex structures. One example is reflection

of shock by a wedge. The complexity of reflection-diffraction configurations

was first described by Ernst Mach in 1878. In later works, experimental and

computational studies and asymptotic analysis have shown that various patterns

of reflected shocks may occur, including regular and Mach reflection. However,

many fundamental issues related to shock reflection are not understood,

including transition between different reflection patterns. For this reason

it is important to establish mathematical theory of shock reflection,

in particular existence and stability of regular reflection solutions for PDEs

of gas dynamics. Some results in this direction were obtained recently.

\\

In this talk we start by discussing examples of shocks in supersonic and

transonic flows of gas. Then we introduce the basic equations of gas dynamics:

steady and self-similar compressible Euler system and potential flow equation.

These equations are of mixed elliptic-hyperbolic type. Subsonic and supersonic

regions in the flow correspond to elliptic and hyperbolic regions of solutions.

Shocks correspond to certain discontinuities in the solutions. We discuss some

results on existence and stability of steady and self-similar shock solutions,

in particular the recent work (joint with G.-Q. Chen) on global existence of

regular reflection solutions for potential flow. We also discuss open problems

in the area.

\\

\\{\bf 3. Title: Shallow water waves - a rich source of interesting solitary wave

solutions to PDEs

\\ Speaker: Prof. Paul H. Taylor, Keble College and Department of Engineering Science, Oxford}

\\

\\Abstract:\\ In shallow water, solitary waves are ubiquitous: even the wave crests

in a train of regular waves can be modelled as a succession of solitary waves.

When successive crests are of different size, they interact when the large ones

catch up with the smaller. Then what happens? John Scott Russell knew by experiment

in 1844, but answering this question mathematically took 120 years!

This talk will examine solitary wave interactions in a range of PDEs, starting

with the earliest from Korteweg and De Vries, then moving onto Peregrine's

regularized long wave equation and finally the recently introduced Camassa-Holm

equation, where solitary waves can be cartoon-like with sharp corners at the crests.

For each case the interactions can be described using the conserved quantities,

in two cases remarkably accurately and in the third exactly, without actually

solving any of the PDEs.

The methodology can be extended to other equations such as the various versions

of the Boussinesq equations popular with coastal engineers, and perhaps even

the full Euler equations.

\\

{\bf 4. Title: Austenite-Martensite interfaces

\\ Speaker: Prof. Sir John Ball, Queen's College and Mathematical Institute, Oxford}

\\

\\Abstract:\\ Many alloys undergo martensitic phase transformations

in which the underlying crystal lattice undergoes a change of shape

at a critical temperature. Usually the high temperature phase (austenite)

has higher symmetry than the low temperature phase (martensite).

In order to nucleate the martensite it has to somehow fit geometrically

to the austenite. The talk will describe different ways in which this

occurs and how they may be studied using nonlinear elasticity and

Young measures.

\\

\\{\bf 5. Title: Partial Differential Equations in Liquid Crystal Science and

Industrial Applications

\\ Speaker: Dr. Apala Majumdar, Keble College and Mathematical Institute, Oxford}

\\

\\Abstract:\\

Recent years have seen a growing demand for liquid crystals in modern

science, industry and nanotechnology. Liquid crystals are mesophases or

intermediate phases of matter between the solid and liquid phases of

matter, with very interesting physical and optical properties.

We briefly review the main mathematical theories for liquid crystals and

discuss their analogies with mathematical theories for other soft-matter

phases such as the Ginzburg-Landau theory for superconductors. The

governing equations for the static and dynamic behaviour are typically

given by systems of coupled elliptic and parabolic partial differential

equations. We then use this mathematical framework to model liquid crystal

devices and demonstrate how mathematical modelling can be used to make

qualitative and quantitative predictions for practical applications in

industry.

\\

\\{\bf 6. Title: Bubble bath, shock waves, and random walks --- Mathematical

models of clustering

\\Speaker: Prof. Robert Pego, Carnegie Mellon University, USA}

\\Abstract:\\ Mathematics is often about abstracting complicated phenomena into

simple models. This talk is about equations that model aggregation

or clustering phenomena --- think of how aerosols form soot particles

in the atmosphere, or how interplanetary dust forms comets, planets

and stars. Often in such complex systems one observes universal trend

toward self-similar growth. I'll describe an explanation for this

phenomenon in two simple models describing: (a) ``one-dimensional

bubble bath,'' and (b) the clustering of random shock waves.

Thu, 10 Jun 2010
13:00
DH 1st floor SR

Behavioral mean-variance portfolio selection in continuous time via quantile

Junna Bi
(Oxford)
Abstract

A behavioral mean-variance portfolio selection problem in continuous time is formulated and studied. Based on the standard mean-variance portfolio selection problem, the cumulative distribution function of the cash flow is distorted by a probability distortion function. Then the problem is no longer a convex optimization problem. This feature distinguishes it from the conventional linear-quadratic (LQ) problems.

The stochastic optimal LQ control theory no longer applies. We take the quantile function of the terminal cash flow as the decision variable.

The corresponding optimal terminal cash flow can be recovered by the optimal quantile function. Then the efficient strategy is the hedging strategy of the optimal terminal cash flow.

Thu, 10 Jun 2010

12:00 - 13:00
SR1

Geometry with torsion and multi-moment maps

Thomas Bruun Madsen
(Odense)
Abstract

On any Hermitian manifold there is a unique Hermitian connection, called the Bismut connection, which has torsion a three-form. One says that the triplet consisting of the Hermitian structure together with the Bismut connection specifies a Kähler-with-torsion structure, or briefly a KT structure. If the torsion three-form is closed, we have a strong KT structure. The first part of this talk will discuss these notions and also address the problem of classifying strong KT structures.

\paragraph{} Despite their name, KT manifolds are generally not Kähler. In particular the fundamental two-form is not closed. If the KT structure is strong, we have instead a closed three-form. Motivated by the usefulness of moment maps in geometries involving symplectic forms, one may ask whether it is possible to construct a similar type of map, when we replace the symplectic form by a closed three-form. The second part of the talk will explain the construction of such maps, which are called multi-moment maps.

Thu, 10 Jun 2010
10:00
Gibson 1st Floor SR

Lecture Series: Scaling Dynamics in Aggregation Models

Professor Bob Pego
(Carnegie Mellon University)
Abstract

Clustering phenomena occur in numerous areas of science. This series of lectures will discuss:

(i) basic kinetic models for clustering- Smoluchowski's coagulation equation, random shock clustering, ballistic aggregation, domain-wall merging;

(ii) Criteria for approach to self-similarity- role of regular variation;

(iii) The scaling attractor and its measure representation. A particular theme is the use of methods and insights from probability in tandem with dynamical systems theory. In particular there is a

close analogy of scaling dynamics with the stable laws of probability and infinite divisibility.

Thu, 10 Jun 2010
09:00
L3

Twisted Topological Field Theory in Dimensions 1 and 2 K-Theory and elliptic Cohomology

Chris Douglas
Abstract

Homology counts components and cycles, K-theory counts vector bundles and bundles of Clifford algebra modules.  What about geometric models for other generalized cohomology theories?  There is a vision, introduced by Segal, Stolz, and Teichner, that certain cohomology theories should be expressible in terms of topological field theories.

I will describe how the 0-th K-theory group can be formulated in terms of equivalence classes of 1-dimensional topological field theories.  Then I will discuss what it means to twist a topological field theory, and explain that the n-th K-theory group comes from twisted 1-dimensional topological field theories.

The expectation is that 2-dimensional topological field theories should be analogously related to elliptic cohomology.  I will take an extended digression to explain what elliptic cohomology is and why it is interesting.  Then I will discuss 2-dimensional twisted field theory and explain how it leads us toward a notion of higher

("2-dimensional") algebra.  

 

 

Based on joint work with Arthur Bartels and Andre Henriques
Wed, 09 Jun 2010

11:30 - 12:30
ChCh, Tom Gate, Room 2

The Hanna Neumann Conjecture

Dawid Kielak
(University of Oxford)
Abstract

We will introduce both the classical Hanna Neumann Conjecture and its strengthened version, discuss Stallings' reformulation in terms of immersions of graphs, and look at some partial results. If time allows we shall also look at the new approach of Joel Friedmann.

Wed, 09 Jun 2010
09:00
L3

Vector Bundles and K-Theory, Clifford Algebras and Bott Perodicity

Chris Douglas
Abstract

Ordinary homology is a geometrically defined invariant of spaces: the 0-th homology group counts the number of components; the n-th homology group counts n-cycles, which correspond to an intuitive notion of 'n-dimensional holes' in a space.  K-theory, or more specifically the 0-th K-theory group, is defined in terms of vector bundles, and so also has an immediate relationship to geometry.  By contrast, the n-th K-theory group is typically defined homotopy-theoretically using the black box of Bott periodicity.

I will describe a more geometric perspective on K-theory, using Z/2-graded vector bundles and bundles of modules for Clifford algebras.  Along the way I will explain Clifford algebras, 2-categories, and Morita equivalence, explicitly check the purely algebraic 8-fold periodicity of the Clifford algebras, and discuss how and why this periodicity implies Bott periodicity.

The talk will not presume any prior knowledge of K-theory, Clifford algebras, Bott periodicity, or the like.

 

 

Based on joint work with Arthur Bartels and Andre Henriques
Tue, 08 Jun 2010
16:00
DH 3rd floor SR

Bounded cohomology and quasi-homomorphisms

Richard Wade
(Oxford)
Abstract

Starting from a definition of the cohomology of a group, we will define the bounded cohomology of a group. We will then show how quasi-homomorphisms lead to cocycles in the second bounded cohomology group, and use this to look at the second bounded cohomology of some of our favourite groups. If time permits we will end with some applications.

Tue, 08 Jun 2010

14:30 - 15:30
L3

Rigidity of direction-length frameworks

Bill Jackson
(QMUL)
Abstract

Consider a configuration of points in $d$-dimensional Euclidean space

together with a set of constraints

which fix the direction or the distance between some pairs of points.

Basic questions are whether the constraints imply that the configuration

is unique or locally unique up to congruence, and whether it is bounded. I

will describe some solutions

and partial solutions to these questions.

Tue, 08 Jun 2010

12:00 - 13:00
L3

G_2 structures, rational curves, and ODEs

Dr Dunajski
(DAMTP)
Abstract

Consider the space M of parabolas y=ax^2+bx+c, with (a, b, c) as coordinates on M. Two parabolas generically intersect at two (possibly complex) points, and we can define a conformal structure on M by declaring two points to be null separated iff the corresponding parabolas are tangent. A simple calculation of discriminant shows that this conformal structure is flat.

In this talk (based on joint works with Godlinski and Sokolov) I shall show how replacing parabolas by rational plane curves of higher degree allows constructing curved conformal structures in any odd dimension. In dimension seven one can use this "twistor" construction to find G_2 structures in a conformal class.

Mon, 07 Jun 2010

17:00 - 18:00
Gibson 1st Floor SR

Shock Reflection and Free Boundary Problems

Mikhail Feldman
(University of Wisconsin at Madison)
Abstract

In this talk we describe some recent work on shock

reflection problems for the potential flow equation. We will

start with discussion of shock reflection phenomena. Then we

will describe the results on existence, structure and

regularity of global solutions to regular shock reflection. The

approach is to reduce the shock reflection problem to a free

boundary problem for a nonlinear elliptic equation, with

ellipticity degenerate near a part of the boundary (the sonic

arc). We will discuss techniques to handle such free boundary

problems and degenerate elliptic equations. This talk is based

on joint works with Gui-Qiang Chen, and with Myoungjean Ba

Mon, 07 Jun 2010

12:00 - 13:00
L3

The torsional conifold: fivebranes and the Klebanov-Strassler theory

Dario Martelli
(Kings College London)
Abstract
We study a gravity solution corresponding to fivebranes wrapped on the S^2 of the resolved conifold. By changing a parameter the solution continuously interpolates between the deformed conifold with flux and the resolved conifold with branes. Therefore, it displays a geometric transition, purely in the supergravity context. The solution is a simple example of torsional geometry and may be thought of as a non-Kahler analog of the conifold. By U-duality transformations we can add D3 brane charge and recover the solution in the form originally derived by Butti et al. This describes the baryonic branch of the Klebanov-Strassler theory. Far along the baryonic branch the field theory gives rise to a fuzzy two-sphere. This corresponds to the D5 branes wrapping the two-sphere of the resolved conifold in the gravity solution.
Fri, 04 Jun 2010

17:00 - 18:00
L3

Sudoku... More than just a game

Tristan Denley
(Austin Peay)
Abstract

Whether as the sudoku puzzles of popular culture or as

restricted coloring problems on graphs or hypergraphs, completing partial

Latin squares and cubes present a framework for a variety of intriguing

problems. In this talk we will present several recent results on

completing partial Latin squares and cubes.

Fri, 04 Jun 2010
14:15
DH 1st floor SR

An overview of some recent progress in incomplete-market equilibria

Gordan Zitkovic
(UT Austin)
Abstract

In addition to existence, the excess-demand approach allows us to establish uniqueness and provide efficient computational algorithms for various complete- and incomplete-market stochastic financial equilibria.

A particular attention will be paid to the case when the agents exhibit constant absolute risk aversion. An overview of recent results (including those jointly obtained with M. Anthropelos and with Y. Zhao) will be given.

Fri, 04 Jun 2010

11:30 - 12:30
Gibson 1st Floor SR

T-duality in AdS$_5$

Ron Reid-Edwards
(Oxford)
Abstract

This will discuss the paper of Ricci, Tseytlin & Wolf from 2007.

Fri, 04 Jun 2010

10:00 - 13:00
DH 1st floor SR

Compressive sampling of radar and electronic warfare data

Andy Stove
(Thales)
Abstract

'Compressive sampling' is a topic of current interest. It relies on data being sparse in some domain, which allows what is apparently 'sub Nyquist' sampling so that the quantities of data which must be handled become more closely related to the information rate. This principal would appear to have (at least) three applications for radar and electronic warfare: \\

The most modest application is to reduce the amount of data which we must handle: radar and electronic warfare receivers generate vast amounts of data (up to 1Gbit/second or even 10Gbit.sec). It is desirable to be able to store this data for future analysis and it is also becoming increasingly important to be able to share it between different sensors, which, prima facie, requires vast communication bandwidths and it would be valuable to be able to find ways to handle this more efficiently. \\

The second advantage is that if suitable data domains can be identified, it may also be possible to pre-process the data before the analogue to digital converters in the receivers, to reduce the demands on these critical components. \\

The most ambitious use of compressive sensing would be to find ways of modifying the radar waveforms, and the electronic warfare receiver sampling strategies, to change the domain in which the information is represented to reduce the data rates at the receiver 'front ends', i.e. make the data at the front end better match the information we really want to acquire.\\

The aim of the presentation will be to describe the issues with which we are faced, and to discuss how compressive sampling might be able to help. A particular issue which will be raised is how we might find domains in which the data is sparse.

Thu, 03 Jun 2010
17:00
L3

Topos Quantum Logic

Andreas Doering
(Oxford)
Abstract

Standard quantum logic, as intitiated by Birkhoff and von Neumann, suffers from severe problems which relate quite directly to interpretational issues in the foundations of quantum theory. In this talk, I will present some aspects of the so-called topos approach to quantum theory, as initiated by Isham and Butterfield, which aims at a mathematical reformulation of quantum theory and provides a new, well-behaved form of quantum logic that is based upon the internal logic of a certain (pre)sheaf topos.

Thu, 03 Jun 2010

16:30 - 17:30
DH 1st floor SR

Structured media with defects: asymptotic models and localisation

Alexander Movchan
(University of Liverpool)
Abstract

Bloch Floquet waves are considered in structured media. Such waves are dispersive and the dispersion diagrams contain stop bands. For an example of a harmonic lattice, we discuss dynamic band gap Green’s functions characterised by exponential localisation. This is followed by simple models of exponentially localised defect modes. Asymptotic models involving uniform asymptotic approximations of physical fields in structured media are compared with homogenisation approximations.

Thu, 03 Jun 2010

12:00 - 13:00
SR1

Cohomology of moduli spaces

Oscar Randal-Williams
(Oxford)
Abstract

I will discuss what is known about the cohomology of several moduli spaces coming from algebraic and differential geometry. These are: moduli spaces of non-singular curves (= Riemann surfaces) $M_g$, moduli spaces of nodal curves $\overline{M}_g$, moduli spaces of holomorphic line bundles on curves $Hol_g^k \to M_g$, and the universal Picard varieties $Pic^k_g \to M_g$. I will construct characteristic classes on these spaces, talk about their homological stability, and try to explain why the constructed classes are the only stable ones. If there is time I will also talk about the Picard groups of these moduli spaces.

Much of this work is due to other people, but some is joint with J. Ebert.

Tue, 01 Jun 2010

17:00 - 18:00
L2

The cluster category of Dynkin type $A_\infty$

Peter Jorgensen
(Newcastle)
Abstract

\ \ The cluster category of Dynkin type $A_\infty$ is a ubiquitous object with interesting properties, some of which will be explained in this talk.

\\

\ \ Let us denote the category by $\mathcal{D}$. Then $\mathcal{D}$ is a 2-Calabi-Yau triangulated category which can be defined in a standard way as an orbit category, but it is also the compact derived category $D^c(C^{∗}(S^2;k))$ of the singular cochain algebra $C^*(S^2;k)$ of the 2-sphere $S^{2}$. There is also a “universal” definition: $\mathcal{D}$ is the algebraic triangulated category generated by a 2-spherical object. It was proved by Keller, Yang, and Zhou that there is a unique such category.

\\

\ \ Just like cluster categories of finite quivers, $\mathcal{D}$ has many cluster tilting subcategories, with the crucial difference that in $\mathcal{D}$, the cluster tilting subcategories have infinitely many indecomposable objects, so do not correspond to cluster tilting objects.

\\

\ \ The talk will show how the cluster tilting subcategories have a rich combinatorial

structure: They can be parametrised by “triangulations of the $\infty$-gon”. These are certain maximal collections of non-crossing arcs between non-neighbouring integers.

\\

\ \ This will be used to show how to obtain a subcategory of $\mathcal{D}$ which has all the properties of a cluster tilting subcategory, except that it is not functorially finite. There will also be remarks on how $\mathcal{D}$ generalises the situation from Dynkin type $A_n$ , and how triangulations of the $\infty$-gon are new and interesting combinatorial objects.

Tue, 01 Jun 2010

15:45 - 16:45
L3

(HoRSe seminar) Realizations of motives

Denis-Charles Cisinski
(Paris 13)
Abstract

A categorification of cycle class maps consists to define

realization functors from constructible motivic sheaves to other

categories of coefficients (e.g. constructible $l$-adic sheaves), which are compatible with the six operations. Given a field $k$, we

will describe a systematic construction, which associates,

to any cohomology theory $E$, represented in $DM(k)$, a

triangulated category of constructible $E$-modules $D(X,E)$, for $X$

of finite type over $k$, endowed with a realization functor from

the triangulated category of constructible motivic sheaves over $X$.

In the case $E$ is either algebraic de Rham cohomology (with $char(k)=0$), or $E$ is $l$-adic cohomology, one recovers in this way the triangulated categories of $D$-modules or of $l$-adic sheaves. In the case $E$ is rigid cohomology (with $char(k)=p>0$), this construction provides a nice system of $p$-adic coefficients which is closed under the six operations.

Tue, 01 Jun 2010

14:30 - 15:30
L3

Subspaces in sumsets: a problem of Bourgain and Green

Tom Sanders
(Cambridge)
Abstract

Suppose that $A \subset \mathbb F_2^n$ has density $\Omega(1)$. How

large a subspace is $A+A:=\{a+a’:a,a’ \in A\}$ guaranteed to contain? We

discuss this problem and how the the result changes as the density

approaches $1/2$.

Tue, 01 Jun 2010

14:00 - 15:00
L2

(HoRSe seminar) Motivic sheaves over excellent schemes

Denis-Charles Cisinski
(Paris 13)
Abstract

Starting from Morel and Voevodsky's stable homotopy theory of schemes, one defines, for each noetherian scheme of finite dimension $X$, the triangulated category $DM(X)$ of motives over $X$ (with rational coefficients). These categories satisfy all the the expected functorialities (Grothendieck's six operations), from

which one deduces that $DM$ also satisfies cohomological proper

descent. Together with Gabber's weak local uniformisation theorem,

this allows to prove other expected properties (e.g. finiteness

theorems, duality theorems), at least for motivic sheaves over

excellent schemes.

Tue, 01 Jun 2010

13:15 - 13:45
DH 1st floor SR

Towards a Colonic Crypt Model with a Realistic, Deformable Geometry

Sara-Jane Dunn
(Oxford)
Abstract

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide, demanding a response from scientists and clinicians to understand its aetiology and develop effective treatment. CRC is thought to originate via genetic alterations that cause disruption to the cellular dynamics of the crypts of Lieberkűhn, test-tube shaped glands located in both the small and large intestine, which are lined with a monolayer of epithelial cells. It is believed that during colorectal carcinogenesis, dysplastic crypts accumulate mutations that destabilise cell-cell contacts, resulting in crypt buckling and fission. Once weakened, the corrupted structure allows mutated cells to migrate to neighbouring crypts, to break through to the underlying tissue and so aid the growth and malignancy of a tumour. To provide further insight into the tissue-level effects of these genetic mutations, a multi-scale model of the crypt with a realistic, deformable geometry is required. This talk concerns the progress and development of such a model, and its usefulness as a predictive tool to further the understanding of interactions across spatial scales within the context of colorectal cancer.