Modelling cell migration in the mouse embryo
Abstract
The visceral endoderm (VE) is an epithelium of approximately 200 cells
encompassing the early post-implantation mouse embryo. At embryonic day
5.5, a subset of around 20 cells differentiate into morphologically
distinct tissue, known as the anterior visceral endoderm (AVE), and
migrate away from the distal tip, stopping abruptly at the future
anterior. This process is essential for ensuring the correct orientation
of the anterior-posterior axis, and patterning of the adjacent embryonic
tissue. However, the mechanisms driving this migration are not clearly
understood. Indeed it is unknown whether the position of the future
anterior is pre-determined, or defined by the movement of the migrating
cells. Recent experiments on the mouse embryo, carried out by Dr.
Shankar Srinivas (Department of Physiology, Anatomy and Genetics) have
revealed the presence of multicellular ‘rosettes’ during AVE migration.
We are developing a comprehensive vertex-based model of AVE migration.
In this formulation cells are treated as polygons, with forces applied
to their vertices. Starting with a simple 2D model, we are able to mimic
rosette formation by allowing close vertices to join together. We then
transfer to a more realistic geometry, and incorporate more features,
including cell growth, proliferation, and T1 transitions. The model is
currently being used to test various hypotheses in relation to AVE
migration, such as how the direction of migration is determined, what
causes migration to stop, and what role rosettes play in the process.
12:00
Characterization and Rigidity of the Kerr-Newman Solution
Abstract
A celebrated result in mathematical general relativity is the uniqueness of the Kerr(-Newman) black-holes as regular solutions to the stationary and axially-symmetric Einstein(-Maxwell) equations. The axial symmetry can be removed if one invokes Hawking's rigidity theorem. Hawking's theorem requires, however, real analyticity of the solution. A recent program of A. Ionescu and S. Klainerman seeks to remove the analyticity requirement in the vacuum case. They were able to show that any smooth extension of "Kerr data" prescribed on the horizon, satisfying the Einstein vacuum equations, must be Kerr, using a characterization of Kerr metric due to M. Mars. In this talk I will give a characterization for the Kerr-Newman metric, and extend the rigidity result to cover the electrovacuum case.
Global regular solutions to the Navier-Stokes equations in a cylinder with slip boundary conditions
Abstract
We consider the motion of a viscous incompressible fluid described by
the Navier-Stokes equations in a bounded cylinder with slip boundary
conditions. Assuming that $L_2$ norms of the derivative of the initial
velocity and the external force with respect to the variable along the
axis of the cylinder are sufficiently small we are able to prove long
time existence of regular solutions. By the regular solutions we mean
that velocity belongs to $W^{2,1}_2 (Dx(0,T))$ and gradient of pressure
to $L_2(Dx(0,T))$. To show global existence we prolong the local solution
with sufficiently large T step by step in time up to infinity. For this purpose
we need that $L_2(D)$ norms of the external force and derivative
of the external force in the direction along the axis of the cylinder
vanish with time exponentially.
Next we consider the inflow-outflow problem. We assume that the normal
component of velocity is nonvanishing on the parts of the boundary which
are perpendicular to the axis of the cylinder. We obtain the energy type
estimate by using the Hopf function. Next the existence of weak solutions is
proved.
15:45
On spaces of homomorphisms and spaces of representations
Abstract
The subject of this talk is the structure of the space of homomorphisms from a free abelian group to a Lie group G as well as quotients spaces given by the associated space of representations.
These spaces of representations admit the structure of a simplicial space at the heart of the work here.
Features of geometric realizations will be developed.
What is the fundamental group or the first homology group of the associated space in case G is a finite, discrete group ?
This deceptively elementary question as well as more global information given in this talk is based on joint work with A. Adem, E. Torres, and J. Gomez.
15:45
Hermite polynomial aliasing in Gaussian quadrature
Abstract
A representation of Hermite polynomials of degree 2n + 1, as sum of an element in the polynomial ideal generated by the roots of the Hermite polynomial of degree n and of a reminder, suggests a folding of multivariate polynomials over a finite set of points. From this, the expectation of some polynomial combinations of random variables normally distributed is computed. This is related to quadrature formulas and has strong links with designs of experiments.
This is joint work with G. Pistone
14:15
Ergodicity of Hypoelliptic SDEs Driven by Fractional Brownian Motion
Abstract
We demonstrate that stochastic differential equations (SDEs) driven by fractional Brownian motion with Hurst parameter H > 1/2 have similar ergodic properties as SDEs driven by standard Brownian motion. The focus in this article is on hypoelliptic systems satisfying H\"ormander's condition. We show that such systems satisfy a suitable version of the strong Feller property and we conclude that they admit a unique stationary solution that is physical in the sense that it does not "look into the future".
The main technical result required for the analysis is a bound on the moments of the inverse of the Malliavin covariance matrix, conditional on the past of the driving noise.
New approaches to problems posed by Sir Roger Penrose
Abstract
I will outline two areas currently under study by myself and my co-workers, particularly Jonathan Holland: one concerns the relation between the exceptional Lie group G_2 and Einstein's gravity; the second will introduce and apply the concept of a causal geometry.
14:15
Finite Resource Valuations: Myths, Theory and Practise
Abstract
Abstract: The valuation of a finite resource, be it acopper mine, timber forest or gas field, has received surprisingly littleattention from the academic literature. The fact that a robust, defensible andaccurate valuation methodology has not been derived is due to a mixture ofdifficulty in modelling the numerous stochastic uncertainties involved and thecomplications with capturing real day-to-day mining operations. The goal ofproducing such valuations is not just for accounting reasons, but also so thatoptimal extraction regimes and procedures can be devised in advance for use atthe coal-face. This paper shows how one can begin to bring all these aspectstogether using contingent claims financial analysis, geology, engineering,computer science and applied mathematics.
14:00
Compression of Synthetic Aperture Radar Images
Abstract
Synthetic Aperture Radars (SARs) produce high resolution images over large areas at high data rates. An aircraft flying at 100m/s can easily image an area at a rate of 1square kilometre per second at a resolution of 0.3x0.3m, i.e. 10Mpixels/sec with a dynamic range of 60-80dB (10-13bits). Unlike optical images, the SAR image is also coherent and this coherence can be used to detect changes in the terrain from one image to another, for example to detect the distortions in the ground surface which precede volcanic eruptions.
It is clearly very desirable to be able to compress these images before they are relayed from one place to another, most particularly down to the ground from the aircraft in which they are gathered.
Conventional image compression techniques superficially work well with SAR images, for example JPEG 2000 was created for the compression of traditional photographic images and optimised on that basis. However there is conventional wisdom that SAR data is generally much less correlated in nature and therefore unlikely to achieve the same compression ratios using the same coding schemes unless significant information is lost.
Features which typically need to be preserved in SAR images are:
o texture to identify different types of terrain
o boundaries between different types of terrain
o anomalies, such as military vehicles in the middle of a field, which may be of tactical importance and
o the fine details of the pixels on a military target so that it might be recognised.
The talk will describe how Synthetic Aperture Radar images are formed and the features of them which make the requirements for compression algorithms different from electro-optical images and the properties of wavelets which may make them appropriate for addressing this problem. It will also discuss what is currently known about the compression of radar images in general.
16:00
16:00
14:00
On the field with one element
Abstract
We shall explain how to give substance to an old dream of Tits, to invent exotic new zeta functions, and discover the skeleton of algebraic varieties (toric manifolds and tropial geometry).
Split Bregman methods for L1-Regularized Problems with Applications to Image Processing
Abstract
This talk will introduce L1-regularized optimization problems that arise in image processing, and numerical methods for their solution. In particular, we will focus on methods of the split-Bregman type, which very efficiently solve large scale problems without regularization or time stepping. Applications include image
denoising, segmentation, non-local filters, and compressed sensing.
13:00
Introduction to descent theory
Abstract
Descent theory is the art of gluing local data together to global data. Beside of being an invaluable tool for the working geometer, the descent philosophy has changed our perception of space and topology. In this talk I will introduce the audience to the basic results of scheme and descent theory and explain how those can be applied to concrete examples.
11:00
Topos Quantum Logic
Abstract
Standard quantum logic, as intitiated by Birkhoff and von Neumann, suffers from severe problems which relate quite directly to interpretational issues in the foundations of quantum theory. In this talk, I will present some aspects of the so-called topos approach to quantum theory, as initiated by Isham and Butterfield, which aims at a mathematical reformulation of quantum theory and provides a new, well-behaved form of quantum logic that is based upon the internal logic of a certain (pre)sheaf topos.
11:00
Interacting expensive functions on rectangular and spherical domains
11:00
On the field with one element
Abstract
We shall explain how to give substance to an old dream of Tits, to invent exotic new zeta functions, and discover the skeleton of algebraic varieties (toric manifolds and tropical geometry).
10:10
17:00
On the field with one element
Abstract
We shall explain how to give substance to an old dream of Tits, to invent exotic new zeta functions, and discover the skeleton of algebraic varieties (toric manifolds and tropical geometry).
Thom polynomials and the Green-Griffiths conjecture
Abstract
The Green-Griffiths conjecture from 1979 says that every projective algebraic variety $X$ of general type contains a certain proper algebraic subvariety $Y$ such that all nonconstant entire holomorphic curves in $X$ must lie inside $Y$. In this talk we explain that for projective hypersurfaces of degree $d>dim(X)^6$ this is the consequence of a positivity conjecture in global singularity theory.
Decomposition of graphs and $\chi$-boundedness
Abstract
A graph is $\chi$-bounded with a function $f$ is for all induced subgraph H of G, we have $\chi(H) \le f(\omega(H))$. Here, $\chi(H)$ denotes the chromatic number of $H$, and $\omega(H)$ the size of a largest clique in $H$. We will survey several results saying that excluding various kinds of induced subgraphs implies $\chi$-boundedness. More precisely, let $L$ be a set of graphs. If a $C$ is the class of all graphs that do not any induced subgraph isomorphic to a member of $L$, is it true that there is a function $f$ that $\chi$-bounds all graphs from $C$? For some lists $L$, the answer is yes, for others, it is no.
A decomposition theorems is a theorem saying that all graphs from a given class are either "basic" (very simple), or can be partitioned into parts with interesting relationship. We will discuss whether proving decomposition theorems is an efficient method to prove $\chi$-boundedness.
14:15
Stability of solitons for the Schroedinger Equation in Three Dimensions
15:45
15:45
Non-Markovian random walk and nonlinear reaction-transport equations.
Abstract
The main aim is to incorporate the nonlinear term into non-Markovian Master equations for a continuous time random walk (CTRW) with non-exponential waiting time distributions. We derive new nonlinear evolution equations for the mesoscopic density of reacting particles corresponding to CTRW with arbitrary jump and waiting time distributions. We apply these equations to the problem of front propagation in the reaction-transport systems of KPP-type.
We find an explicit expression for the speed of a propagating front in the case of subdiffusive transport.
16:30
Algebraic Geometry and Feynman Amplitudes
Abstract
We shall report on the use of algebraic geometry for the calculation of Feynman amplitudes (work of Bloch, Brown, Esnault and Kreimer). Or how to combine Grothendieck's motives with high energy physics in an unexpected way, radically distinct from string theory.
OCIAM internal seminar
Abstract
Heike Gramberg - Flagellar beating in trypanosomes
Robert Whittaker - High-Frequency Self-Excited Oscillations in 3D Collapsible Tube Flows
Microscopic and macroscopic modeling of active suspensions
Abstract
Micron-sized bacteria or algae operate at very small Reynolds numbers.
In this regime, inertial effects are negligible and, hence, efficient
swimming strategies have to be different from those employed by fish
or bigger animals. Mathematically, this means that, in order to
achieve locomotion, the swimming stroke of a microorganism must break
the time-reversal symmetry of the Stokes equations. Large ensembles of
bacteria or algae can exhibit rich collective dynamics (e.g., complex
turbulent patterns, such as vortices or spirals), resulting from a
combination of physical and chemical interactions. The spatial extent
of these structures typically exceeds the size of a single organism by
several orders of magnitude. One of our current projects in the Soft
and Biological Matter Group aims at understanding how the collective
macroscopic behavior of swimming microorganisms is related to their
microscopic properties. I am going to outline theoretical and
computational approaches, and would like to discuss technical
challenges that arise when one tries to derive continuum equations for
these systems from microscopic or mesoscopic models.
17:00
16:00
Numerical Aspects of Optimization in Finance
Abstract
There is a widespread use of mathematical tools in finance and its
importance has grown over the last two decades. In this talk we
concentrate on optimization problems in finance, in particular on
numerical aspects. In this talk, we put emphasis on the mathematical problems and aspects, whereas all the applications are connected to the pricing of derivatives and are the
outcome of a cooperation with an international finance institution.
As one example, we take an in-depth look at the problem of hedging
barrier options. We review approaches from the literature and illustrate
advantages and shortcomings. Then we rephrase the problem as an
optimization problem and point out that it leads to a semi-infinite
programming problem. We give numerical results and put them in relation
to known results from other approaches. As an extension, we consider the
robustness of this approach, since it is known that the optimality is
lost, if the market data change too much. To avoid this effect, one can
formulate a robust version of the hedging problem, again by the use of
semi-infinite programming. The numerical results presented illustrate
the robustness of this approach and its advantages.
As a further aspect, we address the calibration of models being used in
finance through optimization. This may lead to PDE-constrained
optimization problems and their solution through SQP-type or
interior-point methods. An important issue in this context are
preconditioning techniques, like preconditioning of KKT systems, a very
active research area. Another aspect is the preconditioning aspect
through the use of implicit volatilities. We also take a look at the
numerical effects of non-smooth data for certain models in derivative
pricing. Finally, we discuss how to speed up the optimization for
calibration problems by using reduced order models.
Knots, graphs, and the Alexander polynomial
Abstract
In 2008, Juhasz published the following result, which was proved using sutured Floer homology.
Let $K$ be a prime, alternating knot. Let $a$ be the leading coefficient of the Alexander polynomial of $K$. If $|a|
16:00
Chain Transitivity, Omega-Limit sets an Symbolic Dynamics
Abstract
TBA