Past

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Aggregation refers to the thermodynamically favoured coalescence of individual molecular units (monomers) into dense clusters. The formation of liquid drops in oversaturated vapour, or the precipitation of solids from liquid solutions, are 'everyday' examples. A more exotic example, the crystallization of hydrophobic proteins in lipid bilayers, comes from current biophysics.

This talk begins with the basic physics of the simplest classical model, in which clusters grow by absorbing or expelling monomers, and the free monomers are transported by diffusion. Next, comes the description of three successive 'eras' of the aggregation process: NUCLEATION is the initial creation of clusters whose sizes are sufficiently large that they most likely continue to grow, instead of dissolving back into monomers.

The essential physical idea is growth by unlikely fluctuations past a high free energy barrier. The GROWTH of the clusters after nucleation depletes the initial oversaturation of monomer. The free energy barrier against nucleation increases, effectively shutting off any further nucleation. Finally, the oversaturation is so depleted, that the largest clusters grow only by dissolution of the smallest. This final era is called COARSENING.

The initial rate of nucleation and the evolution of the cluster size distribution during coarsening are the subjects of classical, well known models. The 'new meat' of this talk is a 'global' model of aggregation that quantitates the nucleation era, and provides an effective initial condition for the evolution of the cluster size distribution during growth and coarsening. One by-product is the determination of explicit scales of time and cluster size for all three eras. In particular, if G_* is the initial free energy barrier against nucleation, then the characteristic time of the nucleation era is proportional to exp(2G_*/5k_bT), and the characteristic number of monomers in a cluster during the nucleation era is exp(3G_*/5k_bT). Finally, the 'global' model of aggregation informs the selection of the self similar cluster size distribution that characterizes 'mature' coarsening.

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http://www.maths.ox.ac.uk/

The aim of this talk is to describe several methods for numerically approximating

the integral of a multivariate highly oscillatory function. We begin with a review

of the asymptotic and Filon-type methods developed by Iserles and Nørsett. Using a

method developed by Levin as a point of departure we will construct a new method that

uses the same information as the Filon-type method, and obtains the same asymptotic

order, while not requiring moments. This allows us to integrate over nonsimplicial

domains, and with complicated oscillators.

1. Introduction and survey of the cohomological results

This will be a relatively gentle introduction to the topologist's point of view of Riemann's moduli space followed by a description of its rational and torsion cohomology for large genus.