Direct and indirect P-glycoprotein transfers in MCF7 breast cancer cells.

Author: 

Dyson, J
Foll, F
Magal, P
Noussair, A
Pasquier, J

Publication Date: 

January 2019

Journal: 

Journal of theoretical biology

Last Updated: 

2020-01-21T09:15:21.77+00:00

Volume: 

461

DOI: 

10.1016/j.jtbi.2018.10.040

page: 

239-253

abstract: 

The efflux protein P-glycoprotein (P-gp) is over expressed in many cancer cells and has a known capacity to confer multi-drug resistance to cytotoxic therapies. We provide a mathematical model for the direct cell-to-cell transfer of proteins between cells and the indirect transfer between cells and the surrounding liquid. After a mathematical analysis of the model, we construct an adapted numerical scheme and give some numerical simulations. We observe that we obtain a better fit with the experimental data when we take into account the indirect transfer of the protein released in a dish. This quantity, usually neglected by the experimenters, seems to influence the results.

Symplectic id: 

935890

Submitted to ORA: 

Not Submitted

Publication Type: 

Journal Article