Mathematics of Brain Modelling - Spatial navigation in preclinical and clinical Alzheimer’s disease

Spatial navigation in preclinical and clinical Alzheimer’s disease - Relevance for topological data analysis?

Spatial navigation changes are one of the first symptoms of Alzheimer’s disease and also lead to significant safeguarding issues in patients after diagnosis. Despite their significant implications, spatial navigation changes in preclinical and clinical Alzheimer’s disease are still poorly understood. In the current talk, I will explain the spatial navigation processes in the brain and their relevance to Alzheimer’s disease. I will then introduce our Sea Hero Quest project, which created the first global benchmark data for spatial navigation in ~4.5 million people worldwide via a VR-based game. I will present data from the game, which has allowed to create personalised benchmark data for at-risk-of-Alzheimer’s people. The final part of my talk will explore how real-world environment & entropy impacts on dementia patients getting lost and how this has relevance for GPS technology based safeguarding and car driving in Alzheimer’s disease.