In recent years, duality approaches have yielded new results about the high-dimensional cohomology of several groups and moduli spaces, such as $\operatorname{SL}_n(\mathbb{Z})$ and $\mathcal{M}_g$. I will explain the general strategy of these approaches and survey results that have been obtained so far. To give an example, I will first explain how Borel-Serre duality can be used to show that the rational cohomology of $\operatorname{SL}_n(\mathbb{Z})$ vanishes near its virtual cohomological dimension. This is based on joint work with Miller-Patzt-Sroka-Wilson and builds on results by Church-Farb-Putman. I will then put this into a more general context by giving an overview of analogous results for mapping class groups of surfaces, automorphism groups of free groups and further arithmetic groups such as $\operatorname{SL}_n(\mathcal{O}_K)$ and $\operatorname{Sp}_{2n}(\mathbb{Z})$.
