Fri, 28 Apr 2023
14:00 - 15:00
Dr Stefanie Winkelmann
Zuse Institute Berlin

Abstract: Neurotransmission at chemical synapses relies on the calcium-induced fusion of synaptic vesicles with the presynaptic membrane. The distance of the vesicle to the calcium channels determines the fusion probability and consequently the postsynaptic signal. After a fusion event, both the release site and the vesicle undergo a recovery process before becoming available for reuse again. For all these process components, stochastic effects are widely recognized to play an important role. In this talk, I will present our recent efforts on how to describe and structurally understand neurotransmission dynamics using stochastic modeling approaches. Starting with a linear reaction scheme, a method to directly compute the exact first- and second-order moments of the filtered output signal is proposedFor a modification of the model including explicit recovery steps, the stochastic dynamics are compared to the mean-field approximation in terms of reaction rate equations. Finally, we reflect on spatial extensions of the model, as well as on their approximation by hybrid methods.


A. Ernst, C. Schütte, S. Sigrist, S. Winkelmann. Mathematical Biosciences343, 108760, 2022.

- A. Ernst, N. Unger, C. Schütte, A. Walter, S. Winkelmann. Under Review.


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