Combining computational modelling, deep generative learning and imaging to infer new biology

Deep learning algorithms provide unprecedented opportunities to characterise complex structure in large data, but typically in a manner that cannot easily be interpreted beyond the 'black box'. We are developing methods to leverage the benefits of deep generative learning and computational modelling (e.g. fluid dynamics, solid mechanics, biochemistry), particularly in conjunction with biomedical imaging, to enable new insights into disease to be made. In this talk, I will describe our applications in several areas, including modelling drug delivery in cancer and retinal blood vessel loss in diabetes, and how this is leading us into the development of personalised digital twins.