Mathematics for the mind: network dynamical systems for neurodegenerative disease pathology

Travis Thompson

Can mathematics understand neurodegenerative diseases?  The modern medical perspective on neurological diseases has evolved, slowly, since the 20th century but recent breakthroughs in medical imaging have quickly transformed medicine into a quantitative science.  Today, mathematical modeling and scientific computing allow us to go farther than observation alone.  With the help of  computing, experimental and data-informed mathematical models are leading to new clinical insights into how neurodegenerative diseases, such as Alzheimer's disease, may develop in the human brain.  In this talk, I will overview my work in the construction, analysis and solution of data and clinically-driven mathematical models related to AD pathology.  We will see that mathematical modeling and scientific computing are indeed indispensible for cultivating a data-informed understanding of the brain, AD and for developing potential treatments.

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Simplified battery models via homogenisation  

Robert Timms

Lithium-ion batteries (LIBs) are one of the most popular forms of energy storage for many modern devices, with applications ranging from portable electronics to electric vehicles. Improving both the performance and lifetime of LIBs by design changes that increase capacity, reduce losses and delay degradation effects is a key engineering challenge. Mathematical modelling is an invaluable tool for tackling this challenge: accurate and efficient models play a key role in the design, management, and safe operation of batteries. Models of batteries span many length scales, ranging from atomistic models that may be used to predict the rate of diffusion of lithium within the active material particles that make up the electrodes, right through to models that describe the behaviour of the thousands of cells that make up a battery pack in an electric vehicle. Homogenisation can be used to “bridge the gap” between these disparate length scales, and allows us to develop computationally efficient models suitable for optimising cell design.

The organized movement of intracellular material is part of the functioning of cells and the development of organisms. These flows can arise from the action of molecular machines on the flexible, and often transitory, scaffoldings of the cell. Understanding phenomena in this realm has necessitated the development of new simulation tools, and of new coarse-grained mathematical models to analyze and simulate. In that context, I'll discuss how a symmetry-breaking "swirling" instability of a motor-laden cytoskeleton may be an important part of the development of an oocyte, modeling active material in the spindle, and what models of active, immersed polymers tell us about chromatin dynamics in the nucleus.

The organized movement of intracellular material is part of the functioning of cells and the development of organisms. These flows can arise from the action of molecular machines on the flexible, and often transitory, scaffoldings of the cell. Understanding phenomena in this realm has necessitated the development of new simulation tools, and of new coarse-grained mathematical models to analyze and simulate. In that context, I'll discuss how a symmetry-breaking "swirling" instability of a motor-laden cytoskeleton may be an important part of the development of an oocyte, modeling active material in the spindle, and what models of active, immersed polymers tell us about chromatin dynamics in the nucleus.

Some proteins (in their folded form) are classified as being knotted.

The function of the knotting is mysterious since knotting seemingly

would make the folding process unnecessarily complicated.  To

function, proteins need to fold quickly and reproducibly, and

misfolding can have catastrophic results.  For example, Mad Cow

disease and the human analog, Creutzfeldt-Jakob disease, come from

misfolded proteins.

Traditionally, knotting is only defined for closed curves, where the

topology is trapped in the loop.  However, proteins have free ends, as

well as most of the objects that humans consider as being knotted

(like shoelaces and strings of lights).  Defining knotting in open

curves is tricky and ambiguous.  We consider some definitions of

knotting in open curves and see how one of these definitions is used

to characterize the knotting in proteins.

In this talk, I will discuss a wide range of mechanical systems,
including Hoberman’s sphere, Euler’s disk, a sliding cylinder, the
Dynabee, BB-8, and Littlewood’s hoop, and the research they inspired.
Studies of the dynamics of the cylinder ultimately led to a startup
company while studying Euler’s disk led to sponsored research with a
well-known motorcycle company.

This talk is primarily based on research performed with a number of
former students over the past three decades. including Prithvi Akella,
Antonio Bronars, Christopher Daily-Diamond, Evan Hemingway, Theresa
Honein, Patrick Kessler, Nathaniel Goldberg, Christine Gregg, Alyssa
Novelia, and Peter Varadi over the past three decades.

In a joint work with Peter Ozsvath we have developed algebraic invariants for knots using a family of bordered knot algebras. The goal of this lecture is to review these constructions and discuss some of the latest developments.

Rigidity theorems prove that a group's geometry determines its algebra, typically up to virtual isomorphism. Motivated by rigidity problems, we study graphically discrete groups, which impose a discreteness criterion on the automorphism group of any graph the group acts on geometrically. Classic examples of graphically discrete groups include virtually nilpotent groups and fundamental groups of closed hyperbolic manifolds. We will present new examples, proving this property is not a quasi-isometry invariant. We will discuss action rigidity for free products of residually finite graphically discrete groups. This is joint work with Alex Margolis, Sam Shepherd, and Daniel Woodhouse.

We show that the existence of hyperbolic manifolds fibering over the circle is not a phenomenon confined to dimension 3 by exhibiting some examples in dimension 5. More generally, there are hyperbolic manifolds with perfect circle-valued Morse functions in all dimensions $n\le 5$. As a consequence, there are hyperbolic groups with finite-type subgroups that are not hyperbolic.

The main tool is Bestvina - Brady theory enriched with a combinatorial game recently introduced by Jankiewicz, Norin and Wise. These are joint works with Battista, Italiano, and Migliorini.

Consider simple rank-one Lie groups $SO(n, 1)$, $SU(n, 1)$ and $Sp(n ,1)$ ($n>1$). They are the isometry groups of real, complex and quaternionic hyperbolic spaces respectively.

By a result of Kostant, the trivial representation of $Sp(n ,1)$ is isolated in the space of irreducible unitary representations on Hilbert spaces. That is, $Sp(n ,1)$ has Kazhdan’s property (T) which is equivalent to the vanishing of 1st cohomology of the group in all unitary representations. This is in contrast to the case of $SO(n ,1)$ and $SU(n ,1)$ where they have the Haagerup approximation property, a strong negation of property (T).

This dichotomy between $SO(n ,1)$, $SU(n ,1)$ and $Sp(n ,1)$ disappears when we consider so-called uniformly bounded representations on Hilbert spaces. By a result of Cowling in 1980’s, the trivial representation of $Sp(n ,1)$ is no longer isolated in the space of uniformly bounded representations. Moreover, there is a uniformly bounded representation of $Sp(n ,1)$ with non-zero first cohomology group.

The goal of this talk is to describe these facts.

I will talk about joint work with Andrew Lobb related to Toeplitz's square peg problem, which asks whether every (continuous) Jordan curve in the Euclidean plane contains the vertices of a square. Specifically, we show that every smooth Jordan curve contains the vertices of a cyclic quadrilateral of any similarity class. I will describe the context for the result and its proof, which involves symplectic geometry in a surprising way.