Thu, 29 Feb 2024
17:00
Lecture Theatre 1

Mobilizing Mathematics for the Fight Against Cancer - Trachette Jackson

Trachette Jackson
Further Information

Mathematical oncologists apply mathematical and computational models to every aspect of cancer biology, from tumor initiation to malignant spread and treatment response. A substantial amount of medical research now focuses on the molecular biology of individual tumors to selectively target pathways involved in tumor progression, leading to careful manipulation of these pathways, and new cell-specific approaches to cancer therapy are now being developed. At the same time, advances in cancer immunotherapies have led to a reemergence of their use and effectiveness. Using data-driven computational models is a powerful and practical way to investigate the therapeutic potential of novel combinations of these two very different strategies for clinical cancer treatment.

Trachette will showcase mathematical models designed to optimize targeted drug treatment strategies in combination with immunotherapy, to gain a more robust understanding of how specific tumor mutations affect the immune system and ultimately impact combination therapy. Combined with existing and newly generated experimental data, these models are poised to improve the ability to connect promising drugs for clinical trials and reduce the time and costs of transitioning novel therapeutic approaches from “equations to bench to bedside.”

Trachette Jackson is Professor of Mathematics at the University of Michigan and recipient of many awards for her work in her field and for her commitment to increasing opportunities for girls, women, and underrepresented minority students.

Please email @email to register to attend in person.

The lecture will be broadcast on the Oxford Mathematics YouTube Channel on Thursday 21 March at 5-6pm and any time after (no need to register for the online version).

The Oxford Mathematics Public Lectures are generously supported by XTX Markets.

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 Venugopal, M Abbasi, R Ackermann, M Adams, J Agarwalla, S Aguilar, J Ahlers, M Alameddine, J Amin, N Andeen, K Anton, G Argüelles, C Ashida, Y Athanasiadou, S Axani, S Bai, X Balagopal V, A Baricevic, M Barwick, S Basu, V Bay, R Beatty, J Becker Tjus, J Beise, J Bellenghi, C Benning, C BenZvi, S Berley, D Bernardini, E Besson, D Blaufuss, E Blot, S Bontempo, F Book, J Boscolo Meneguolo, C BOSER, S Botner, O Bottcher, J Bourbeau, E Braun, J Brinson, B Brostean-Kaiser, J Burley, R Busse, R Butterfield, D Campana, M Carloni, K Carnie-Bronca, E Chattopadhyay, S Chau, T Chen, C Chen, Z Chirkin, D Choi, S Clark, B Classen, L Coleman, A Collin, G Connolly, A Conrad, J Coppin, P Correa, P Cowen, D Dave, P DE CLERCQ, C DeLaunay, J Delgado Lopez, D Deng, S Deoskar, K Desai, A Desiati, P de Vries, K de Wasseige, G DeYoung, T Diaz, A Diaz-Velez, J Dittmer, M Domi, A Dujmovic, H DuVernois, M Ehrhardt, T Eller, P Ellinger, E El Mentawi, S Elsässer, D Engel, R Erpenbeck, H Evans, J Evenson, P Fan, K Fang, K Farrag, K Fazely, A Fedynitch, A Feigl, N Fiedlschuster, S Finley, C Fischer, L Fox, D Franckowiak, A Fritz, A Furst, P Gallagher, J Ganster, E Garcia, A Gerhardt, L Ghadimi, A Glaser, C Glauch, T Glüsenkamp, T Goehlke, N Gonzalez, J Goswami, S Grant, D Gray, S Gries, O Griffin, S Griswold, S Groth, K Günther, C Gutjahr, P Haack, C Hallgren, A Halliday, R Halve, L Halzen, F Hamdaoui, H Ha Minh, M Hanson, K Hardin, J Harnisch, A Hatch, P Haungs, A Helbing, K Hellrung, J Henningsen, F Heuermann, L Heyer, N Hickford, S Hidvegi, A Hill, C Hill, G Hoffman, K Hori, S Hoshina, K Hou, W Huber, T Hultqvist, K Hunnefeld, M Hussain, R Hymon, K In, S Ishihara, A Jacquart, M Janik, O Jansson, M Japaridze, G Jeong, M Jin, M Jones, B Kang, D Kang, W Kang, X Kappes, A Kappesser, D Kardum, L Karg, T Karl, M Karle, A Katz, U Kauer, M Kelley, J Khatee Zathul, A Kheirandish, A Kiryluk, J Klein, S Kochocki, A Koirala, R Kolanoski, H Kontrimas, T Kopke, L Kopper, C Koskinen, J Koundal, P Kovacevich, M Kowalski, M Kozynets, T Jayakumar, K Kruiswijk, K Krupczak, E Kumar, A Kun, E Kurahashi, N Lad, N Lagunas Gualda, C Lamoureux, M Larson, M Latseva, S Lauber, F Lazar, J Lee, J Leonard DeHolton, K Leszczynska, A Lincetto, M Liu, Q Liubarska, M Lohfink, E Love, C Lozano Mariscal, C Lu, L Lucarelli, F Luszczak, W Lyu, Y Madsen, J Mahn, K Makino, Y Manao, E Mancina, S Marie Sainte, W Maris, I Marka, S Marka, Z Marsee, M Martinez-Soler, I Maruyama, R Mayhew, F McElroy, T McNally, F Mead, J Meagher, K Mechbal, S Medina, A Meier, M Merckx, Y Merten, L Micallef, J Mitchell, J Montaruli, T Moore, R Morii, Y Morse, B Moulai, M Mukherjee, T Naab, R Nagai, R Nakos, M Naumann, U Necker, J Negi, A Neumann, M Niederhausen, H Nisa, M Noell, A Novikov, A Nowicki, S Pollmann, A O'Dell, V Oehler, M Oeyen, B Olivas, A Orsoe, R Osborn, J O'Sullivan, E Pandya, H Park, N Parker, G Paudel, E Paul, L Pérez de los Heros, C Peterson, J Philippen, S Pizzuto, A Plum, M Ponten, A Popovych, Y Prado Rodriguez, M Pries, B Procter-Murphy, R Przybylski, G Raab, C Rack-Helleis, J Rawlins, K Rechav, Z Rehman, A Reichherzer, P Renzi, G Resconi, E Reusch, S Rhode, W Riedel, B Rifaie, A Roberts, E Robertson, S Rodan, S Roellinghoff, G Rongen, M Rott, C Ruhe, T Ruohan, L Ryckbosch, D Safa, I Saffer, J Salazar-Gallegos, D Sampathkumar, P Sanchez Herrera, S Sandrock, A Santander, M Sarkar, S Savelberg, J Savina, P Schaufel, M Schieler, H Schindler, S Schlickmann, L Schlüter, B Schlüter, F Schmeisser, N Schmidt, T Schneider, J Schröder, F Schumacher, L Schwefer, G Sclafani, S Seckel, D Seikh, M Seunarine, S Shah, R Sharma, A Shefali, S Shimizu, N Silva, M Skrzypek, B Smithers, B Snihur, R Soedingrekso, J Sogaard, A Soldin, D Soldin, P Sommani, G Spannfellner, C Spiczak, G Spiering, C Stamatikos, M Stanev, T Stezelberger, T Sturwald, T Stuttard, T Sullivan, G Taboada, I Ter-Antonyan, S Thiesmeyer, M Thompson, W Thwaites, J Tilav, S Tollefson, K Tönnis, C Toscano, S Tosi, D Trettin, A Tung, C Turcotte, R Twagirayezu, J Ty, B Unland Elorrieta, M Upadhyay, A Upshaw, K Valtonen-Mattila, N Vandenbroucke, J van Eijndhoven, N Vannerom, D van Santen, J Vara, J Veitch-Michaelis, J Vereecken, M Verpoest, S Veske, D Vijai, A Walck, C Weaver, C Weigel, P Weindl, A Weldert, J Wendt, C Werthebach, J Weyrauch, M Whitehorn, N Wiebusch, C Willey, N Williams, D Witthaus, L Wolf, A Wolf, M Wrede, G Xu, X Yanez, J Yildizci, E Yoshida, S Young, R Yu, F Yu, S Yuan, T Zhang, Z Zhelnin, P Zimmerman, M 081 (14 Dec 2023)
Towards the Composition of sub-PeV Cosmic Rays at IceCube
 Saffer, J Abbasi, R Ackermann, M Adams, J Agarwalla, S Aguilar, J Ahlers, M Alameddine, J Amin, N Andeen, K Anton, G Argüelles, C Ashida, Y Athanasiadou, S Axani, S Bai, X Balagopal V, A Baricevic, M Barwick, S Basu, V Bay, R Beatty, J Becker Tjus, J Beise, J Bellenghi, C Benning, C BenZvi, S Berley, D Bernardini, E Besson, D Blaufuss, E Blot, S Bontempo, F Book, J Boscolo Meneguolo, C BOSER, S Botner, O Bottcher, J Bourbeau, E Braun, J Brinson, B Brostean-Kaiser, J Burley, R Busse, R Butterfield, D Campana, M Carloni, K Carnie-Bronca, E Chattopadhyay, S Chau, T Chen, C Chen, Z Chirkin, D Choi, S Clark, B Classen, L Coleman, A Collin, G Connolly, A Conrad, J Coppin, P Correa, P Cowen, D Dave, P DE CLERCQ, C DeLaunay, J Delgado Lopez, D Deng, S Deoskar, K Desai, A Desiati, P de Vries, K de Wasseige, G DeYoung, T Diaz, A Diaz-Velez, J Dittmer, M Domi, A Dujmovic, H DuVernois, M Ehrhardt, T Eller, P Ellinger, E El Mentawi, S Elsässer, D Engel, R Erpenbeck, H Evans, J Evenson, P Fan, K Fang, K Farrag, K Fazely, A Fedynitch, A Feigl, N Fiedlschuster, S Finley, C Fischer, L Fox, D Franckowiak, A Fritz, A Furst, P Gallagher, J Ganster, E Garcia, A Gerhardt, L Ghadimi, A Glaser, C Glauch, T Glüsenkamp, T Goehlke, N Gonzalez, J Goswami, S Grant, D Gray, S Gries, O Griffin, S Griswold, S Groth, K Günther, C Gutjahr, P Haack, C Hallgren, A Halliday, R Halve, L Halzen, F Hamdaoui, H Ha Minh, M Hanson, K Hardin, J Harnisch, A Hatch, P Haungs, A Helbing, K Hellrung, J Henningsen, F Heuermann, L Heyer, N Hickford, S Hidvegi, A Hill, C Hill, G Hoffman, K Hori, S Hoshina, K Hou, W Huber, T Hultqvist, K Hunnefeld, M Hussain, R Hymon, K In, S Ishihara, A Jacquart, M Janik, O Jansson, M Japaridze, G Jeong, M Jin, M Jones, B Kang, D Kang, W Kang, X Kappes, A Kappesser, D Kardum, L Karg, T Karl, M Karle, A Katz, U Kauer, M Kelley, J Khatee Zathul, A Kheirandish, A Kiryluk, J Klein, S Kochocki, A Koirala, R Kolanoski, H Kontrimas, T Kopke, L Kopper, C Koskinen, J Koundal, P Kovacevich, M Kowalski, M Kozynets, T Jayakumar, K Kruiswijk, K Krupczak, E Kumar, A Kun, E Kurahashi, N Lad, N Lagunas Gualda, C Lamoureux, M Larson, M Latseva, S Lauber, F Lazar, J Lee, J Leonard DeHolton, K Leszczynska, A Lincetto, M Liu, Q Liubarska, M Lohfink, E Love, C Lozano Mariscal, C Lu, L Lucarelli, F Luszczak, W Lyu, Y Madsen, J Mahn, K Makino, Y Manao, E Mancina, S Marie Sainte, W Maris, I Marka, S Marka, Z Marsee, M Martinez-Soler, I Maruyama, R Mayhew, F McElroy, T McNally, F Mead, J Meagher, K Mechbal, S Medina, A Meier, M Merckx, Y Merten, L Micallef, J Mitchell, J Montaruli, T Moore, R Morii, Y Morse, B Moulai, M Mukherjee, T Naab, R Nagai, R Nakos, M Naumann, U Necker, J Negi, A Neumann, M Niederhausen, H Nisa, M Noell, A Novikov, A Nowicki, S Pollmann, A O'Dell, V Oehler, M Oeyen, B Olivas, A Orsoe, R Osborn, J O'Sullivan, E Pandya, H Park, N Parker, G Paudel, E Paul, L Pérez de los Heros, C Peterson, J Philippen, S Pizzuto, A Plum, M Ponten, A Popovych, Y Prado Rodriguez, M Pries, B Procter-Murphy, R Przybylski, G Raab, C Rack-Helleis, J Rawlins, K Rechav, Z Rehman, A Reichherzer, P Renzi, G Resconi, E Reusch, S Rhode, W Riedel, B Rifaie, A Roberts, E Robertson, S Rodan, S Roellinghoff, G Rongen, M Rott, C Ruhe, T Ruohan, L Ryckbosch, D Safa, I Salazar-Gallegos, D Sampathkumar, P Sanchez Herrera, S Sandrock, A Santander, M Sarkar, S Savelberg, J Savina, P Schaufel, M Schieler, H Schindler, S Schlickmann, L Schlüter, B Schlüter, F Schmeisser, N Schmidt, T Schneider, J Schröder, F Schumacher, L Schwefer, G Sclafani, S Seckel, D Seikh, M Seunarine, S Shah, R Sharma, A Shefali, S Shimizu, N Silva, M Skrzypek, B Smithers, B Snihur, R Soedingrekso, J Sogaard, A Soldin, D Soldin, P Sommani, G Spannfellner, C Spiczak, G Spiering, C Stamatikos, M Stanev, T Stezelberger, T Sturwald, T Stuttard, T Sullivan, G Taboada, I Ter-Antonyan, S Thiesmeyer, M Thompson, W Thwaites, J Tilav, S Tollefson, K Tönnis, C Toscano, S Tosi, D Trettin, A Tung, C Turcotte, R Twagirayezu, J Ty, B Unland Elorrieta, M Upadhyay, A Upshaw, K Valtonen-Mattila, N Vandenbroucke, J van Eijndhoven, N Vannerom, D van Santen, J Vara, J Veitch-Michaelis, J Venugopal, M Vereecken, M Verpoest, S Veske, D Vijai, A Walck, C Weaver, C Weigel, P Weindl, A Weldert, J Wendt, C Werthebach, J Weyrauch, M Whitehorn, N Wiebusch, C Willey, N Williams, D Witthaus, L Wolf, A Wolf, M Wrede, G Xu, X Yanez, J Yildizci, E Yoshida, S Young, R Yu, F Yu, S Yuan, T Zhang, Z Zhelnin, P Zimmerman, M 137 (10 Jan 2024)
In situ estimation of ice crystal properties at the South Pole using LED calibration data from the IceCube Neutrino Observatory
 Abbasi, R Ackermann, M Adams, J Aggarwal, N Aguilar, J Ahlers, M Ahrens, M Alameddine, J Alves, A Amin, N Andeen, K Anderson, T Anton, G Argüelles, C Ashida, Y Athanasiadou, S Axani, S Bai, X Balagopal, A Baricevic, M Barwick, S Basu, V Bay, R Beatty, J Becker, K Tjus, J Beise, J Bellenghi, C Benda, S BenZvi, S Berley, D Bernardini, E Besson, D Binder, G Bindig, D Blaufuss, E Blot, S Bontempo, F Book, J Borowka, J Meneguolo, C Böser, S Botner, O Böttcher, J Bourbeau, E Braun, J Brinson, B Brostean-Kaiser, J Burley, R Busse, R Campana, M Carnie-Bronca, E Chen, C Chen, Z Chirkin, D Choi, K Clark, B Classen, L Coleman, A Collin, G Connolly, A Conrad, J Coppin, P Correa, P Countryman, S Cowen, D Cross, R Dappen, C Dave, P De Clercq, C DeLaunay, J López, D Dembinski, H Deoskar, K Desai, A Desiati, P de Vries, K de Wasseige, G DeYoung, T Diaz, A Díaz-Vélez, J Dittmer, M Dujmovic, H DuVernois, M Ehrhardt, T Eller, P Engel, R Erpenbeck, H Evans, J Evenson, P Fan, K Fazely, A Fedynitch, A Feigl, N Fiedlschuster, S Fienberg, A Finley, C Fischer, L Fox, D Franckowiak, A Friedman, E Fritz, A Fürst, P Gaisser, T Gallagher, J Ganster, E Garcia, A Garrappa, S Gerhardt, L Ghadimi, A Glaser, C Glüsenkamp, T Glauch, T Goehlke, N Gonzalez, J Goswami, S Grant, D Gray, S Grégoire, T Griswold, S Günther, C Gutjahr, P Haack, C Hallgren, A Halliday, R Halve, L Halzen, F Hamdaoui, H Minh, M Hanson, K Hardin, J Harnisch, A Hatch, P Haungs, A Helbing, K Hellrung, J Henningsen, F Heuermann, L Hickford, S Hill, C Hill, G Hoffman, K Hoshina, K Hou, W Huber, T Hultqvist, K Hünnefeld, M Hussain, R Hymon, K In, S Iovine, N Ishihara, A Jansson, M Japaridze, G Jeong, M Jin, M Jones, B Kang, D Kang, W Kang, X Kappes, A Kappesser, D Kardum, L Karg, T Karl, M Karle, A Katz, U Kauer, M Kelley, J Kheirandish, A Kin, K Kiryluk, J Klein, S Kochocki, A Koirala, R Kolanoski, H Kontrimas, T Köpke, L Kopper, C Koskinen, J Koundal, P Kovacevich, M Kowalski, M Kozynets, T Krupczak, E Kun, E Kurahashi, N Lad, N Gualda, C Larson, M Lauber, F Lazar, J Lee, J Leonard, K Leszczyńska, A Lincetto, M Liu, Q Liubarska, M Lohfink, E Love, C Mariscal, C Lu, L Lucarelli, F Ludwig, A Luszczak, W Lyu, Y Ma, Y Madsen, J Mahn, K Makino, Y Mancina, S Sainte, W Mariş, I Marka, S Marka, Z Marsee, M Martinez-Soler, I Maruyama, R McElroy, T McNally, F Mead, J Meagher, K Mechbal, S Medina, A Meier, M Meighen-Berger, S Merckx, Y Micallef, J Mockler, D Montaruli, T Moore, R Morse, B Moulai, M Mukherjee, T Naab, R Nagai, R Naumann, U Nayerhoda, A Necker, J Neumann, M Niederhausen, H Nisa, M Nowicki, S Pollmann, A Oehler, M Oeyen, B Olivas, A Orsoe, R Osborn, J O'Sullivan, E Pandya, H Pankova, D Park, N Parker, G Paudel, E Paul, L de los Heros, C Peters, L Peterson, J Philippen, S Pieper, S Pizzuto, A Plum, M Popovych, Y Porcelli, A Rodriguez, M Pries, B Procter-Murphy, R Przybylski, G Raab, C Rack-Helleis, J Rameez, M Rawlins, K Rechav, Z Rehman, A Reichherzer, P Renzi, G Resconi, E Reusch, S Rhode, W Richman, M Riedel, B Roberts, E Robertson, S Rodan, S Roellinghoff, G Rongen, M Rott, C Ruhe, T Ruohan, L Ryckbosch, D Cantu, D Safa, I Saffer, J Salazar-Gallegos, D Sampathkumar, P Herrera, S Sandrock, A Santander, M Sarkar, S Schaufel, M Schieler, H Schindler, S Schlüter, B Schmidt, T Schneider, J Schröder, F Schumacher, L Schwefer, G Sclafani, S Seckel, D Seunarine, S Sharma, A Shefali, S Shimizu, N Silva, M Skrzypek, B Smithers, B Snihur, R Soedingrekso, J Søgaard, A Soldin, D Spannfellner, C Spiczak, G Spiering, C Stamatikos, M Stanev, T Stein, R Stezelberger, T Stürwald, T Stuttard, T Sullivan, G Taboada, I Ter-Antonyan, S Thompson, W Thwaites, J Tilav, S Tollefson, K Tönnis, C Toscano, S Tosi, D Trettin, A Tung, C Turcotte, R Twagirayezu, J Ty, B Elorrieta, M Upshaw, K Valtonen-Mattila, N Vandenbroucke, J van Eijndhoven, N Vannerom, D van Santen, J Vara, J Veitch-Michaelis, J Verpoest, S Veske, D Walck, C Wang, W Watson, T Weaver, C Weigel, P Weindl, A Weldert, J Wendt, C Werthebach, J Weyrauch, M Whitehorn, N Wiebusch, C Willey, N Williams, D Wolf, M Wrede, G Wulff, J Xu, X Yanez, J Yildizci, E Yoshida, S Yu, S Yuan, T Zhang, Z Zhelnin, P The Cryosphere volume 18 issue 1 75-102 (04 Jan 2024)
Flashes and rainbows in tournaments
 Girao, A Illingworth, F Michel, L Savery, M Scott, A Combinatorica volume 44 issue 3 675-690 (04 Apr 2024)
Thu, 30 May 2024

14:00 - 15:00
Rutherford Appleton Laboratory, nr Didcot

This seminar has been cancelled

Marta Betcke
(University College London)
Abstract

Joint work Marta Betcke and Bolin Pan

In photoacoustic tomography (PAT) with flat sensor, we routinely encounter two types of limited data. The first is due to using a finite sensor and is especially perceptible if the region of interest is large relatively to the sensor or located farther away from the sensor. In this talk we focus on the second type caused by a varying sensitivity of the sensor to the incoming wavefront direction which can be modelled as binary i.e. by a cone of sensitivity. Such visibility conditions result, in Fourier domain, in a restriction of the data to a bowtie, akin to the one corresponding to the range of the forward operator but further narrowed according to the angle of sensitivity. 

We show how we can separate the visible and invisible wavefront directions in PAT image and data using a directional frame like Curvelets, and how such decomposition allows for decoupling of the reconstruction involving application of expensive forward/adjoint solvers from the training problem. We present fast and stable approximate Fourier domain forward and adjoint operators for reconstruction of the visible coefficients for such limited angle problem and a tailored UNet matching both the multi-scale Curvelet decomposition and the partition into the visible/invisible directions for learning the invisible coefficients from a training set of similar data.

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