Tue, 22 Oct 2024

14:00 - 15:00
L5

Maria Pope: Uncovering Higher-Order Interactions in the Cortex: Applications of Multivariate Information Theory

Maria Pope
(Indiana University)
Abstract

Creating networks of statistical dependencies between brain regions is a powerful tool in neuroscience that has resulted in many new insights and clinical applications. However, recent interest in higher-order interactions has highlighted the need to address beyond-pairwise dependencies in brain activity. Multivariate information theory is one tool for identifying these interactions and is unique in its ability to distinguish between two qualitatively different modes of higher-order interactions: synergy and redundancy. I will present results from applying the O-information, the partial entropy decomposition, and the local O-information to resting state fMRI data. Each of these metrics indicate that higher-order interactions are widespread in the cortex, and further that they reveal different patterns of statistical dependencies than those accessible through pairwise methods alone. We find that highly synergistic subsystems typically sit between canonical functional networks and incorporate brain regions from several of these systems. Additionally, canonical networks as well as the interactions captured by pairwise functional connectivity analyses, are strongly redundancy-dominated. Finally, redundancy/synergy dominance varies in both space and time throughout an fMRI scan with notable recurrence of sets of brain regions engaging synergistically. As a whole, I will argue that higher-order interactions in the brain are an under-explored space that, made accessible with the tools of multivariate information theory, may offer novel insights.

Martin invariants
Panzer, E
Wed, 20 Nov 2024
17:00
Lecture Theatre 1, Mathematical Institute, Radcliffe Observatory Quarter, Woodstock Road, OX2 6GG

Chance, luck, and ignorance: how to put our uncertainty into numbers - David Spiegelhalter

David Spiegelhalter
(University of Cambridge)
Further Information

We all have to live with uncertainty about what is going to happen, what has happened, and why things turned out how they did.  We attribute good and bad events as ‘due to chance’, label people as ‘lucky’, and (sometimes) admit our ignorance.  I will show how to use the theory of probability to take apart all these ideas, and demonstrate how you can put numbers on your ignorance, and then measure how good those numbers are. Along the way we will look at three types of luck, and judge whether Derren Brown was lucky or unlucky when he was filmed flipping ten Heads in a row.

David Spiegelhalter was Cambridge University's first Winton Professor of the Public Understanding of Risk. He has appeared regularly on television and radio and is the author of several books, the latest of which is The Art of Uncertainty: How to Navigate Chance, Ignorance, Risk and Luck (Penguin, September 2024).

Please email @email to register to attend in person.

The lecture will be broadcast on the Oxford Mathematics YouTube Channel on Wednesday 11 December at 5-6pm and any time after (no need to register for the online version).

The Oxford Mathematics Public Lectures are generously supported by XTX Markets.

Thu, 24 Oct 2024
16:00
L6

COW SEMINAR: Derived symmetries for crepant resolutions of hypersurfaces

Will Donovan
(Tsinghua)
Abstract

Given a singularity with a crepant resolution, a symmetry of the derived 
category of coherent sheaves on the resolution may often be constructed 
using the formalism of spherical functors. I will introduce this, and 
new work (arXiv:2409.19555) on general constructions of such symmetries 
for hypersurface singularities. This builds on previous results with 
Segal, and is inspired by work of Bodzenta-Bondal.

Thu, 24 Oct 2024
14:30
L6

COW SEMINAR: Homological mirror symmetry for K3 surfaces

Ailsa Keating
(Cambridge)
Abstract

Joint work with Paul Hacking (U Mass Amherst). We first explain how to 
prove homological mirror symmetry for a maximal normal crossing 
Calabi-Yau surface Y with split mixed Hodge structure. This includes the 
case when Y is a type III K3 surface, in which case this is used to 
prove a conjecture of Lekili-Ueda. We then explain how to build on this 
to prove an HMS statement for K3 surfaces. On the symplectic side, we 
have any K3 surface (X, ω) with ω integral Kaehler; on the algebraic 
side, we get a K3 surface Y with Picard rank 19. The talk will aim to be 
accessible to audience members with a wide range of mirror symmetric 
backgrounds.

Thu, 24 Oct 2024
13:00
L6

COW SEMINAR: Ball quotients and moduli spaces

Klaus Hulek
(Hannover)
Abstract

A number of moduli problems are, via Hodge theory, closely related to 
ball quotients. In this situation there is often a choice of possible 
compactifications such as the GIT compactification´and its Kirwan 
blow-up or the Baily-Borel compactification and the toroidal 
compactificatikon. The relationship between these compactifications is 
subtle and often geometrically interesting. In this talk I will discuss 
several cases, including cubic surfaces and threefolds and 
Deligne-Mostow varieties. This discussion links several areas such as 
birational geometry, moduli spaces of pointed curves, modular forms and 
derived geometry. This talk is based on joint work with S. 
Casalaina-Martin, S. Grushevsky, S. Kondo, R. Laza and Y. Maeda.

Thu, 07 Nov 2024

17:00 - 18:00
L3

Ramification Theory for Henselian Valued Fields

Vaidehee Thatte
(King's College London)
Abstract

Ramification theory serves the dual purpose of a diagnostic tool and treatment by helping us locate, measure, and treat the anomalous behavior of mathematical objects. In the classical setup, the degree of a finite Galois extension of "nice" fields splits up neatly into the product of two well-understood numbers (ramification index and inertia degree) that encode how the base field changes. In the general case, however, a third factor called the defect (or ramification deficiency) can pop up. The defect is a mysterious phenomenon and the main obstruction to several long-standing open problems, such as obtaining resolution of singularities. The primary reason is, roughly speaking, that the classical strategy of "objects become nicer after finitely many adjustments" fails when the defect is non-trivial. I will discuss my previous and ongoing work in ramification theory that allows us to understand and treat the defect.

Wed, 23 Oct 2024
16:00
L6

Coherence in Dimension 2

Sam Fisher
(University of Oxford)
Abstract

A group is coherent if all its finitely generated subgroups are finitely presented. Aside from some easy cases, it appears that coherence is a phenomenon that occurs only among groups of cohomological dimension 2. In this talk, we will give many examples of coherent and incoherent groups, discuss techniques to prove a group is coherent, and mention some open problems in the area.

Fri, 25 Oct 2024
12:00
L2

Twisted eleven-dimensional supergravity and exceptional simple infinite dimensional super-Lie algebras

Surya Raghavendran
(Edinburgh)
Abstract

I will describe a holomorphic-topological field theory in eleven-dimensions which captures a 1/16-BPS subsector of eleven-dimensional supergravity. Remarkably, asymptotic symmetries of the theory on flat space and on twisted versions of the AdS_4 x S^7 and AdS_7 x S^4 backgrounds recover three of the five infinite dimensional exceptional simple super-Lie algebras. I will discuss some applications of this fact, including character formulae for indices counting multigravitons and the contours of a program to holographically describe 1/16-BPS local operators in the 6d (2,0) SCFTs of type A_{N-1}. This talk is based on joint work, much in progress, with Fabian Hahner, Ingmar Saberi, and Brian Williams.

Characterising cancer cell responses to cyclic hypoxia using mathematical modelling
Celora, G Nixson, R Pitt-Francis, J Maini, P Byrne, H Bulletin of Mathematical Biology volume 86 issue 12 (06 Nov 2024)
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