16:30
Viscoelastic models for tumour growth
Abstract
In this talk, we present a mathematical model for tumour growth that incorporates viscoelastic effects. Starting from a basic system of PDEs, we gradually introduce the relevant biological and physical mechanisms and explain how they are integrated into the model. The resulting system features a Cahn--Hilliard type equation for the tumour cells coupled to a convection-reaction-diffusion equation for a nutrient species, and a viscoelastic subsystem for an internal velocity.
Key biological processes such as active transport, apoptosis, and proliferation are modeled via source and sink terms as well as cross-diffusion effects. The viscoelastic behaviour is described using the Oldroyd-B model, which is based on a multiplicative decomposition of the deformation gradient to account for elasticity alongside growth and relaxation effects.
We will highlight several of these effects through numerical simulations.
Moreover, we discuss the main analytical and numerical challenges. Particular focus will be given to the treatment of source and cross-diffusion terms, the elastic energy density, and the difficulties arising from the viscoelastic subsystem. The main analytical result is the global-in-time existence of weak solutions in two spatial dimensions, under the assumption of additional viscoelastic diffusion in the Oldroyd-B equation.
This work is based on joint work with Harald Garcke (University of Regensburg, Germany) and Balázs Kovács (University of Paderborn, Germany).