Topological data analysis, and in particular persistent homology, has provided robust results for numerous applications, such as protein structure, cancer detection, and material science. In the field of neuroscience, the applications of TDA are abundant, ranging from the analysis of single cells to the analysis of neuronal networks. The topological representation of branching trees has been successfully used for a variety of classification and clustering problems of neurons and microglia, demonstrating a successful path of applications that go from the space of trees to the space of barcodes. In this talk, I will present some recent results on topological representation of brain cells, with a focus on neurons. I will also describe our solution for solving the inverse TDA problem on neurons: how can we efficiently go from persistence barcodes back to the space of neuronal trees and what can we learn in the process about these spaces. Finally, I will demonstrate how algebraic topology can be used to understand the links between single neurons and networks and start understanding the brain differences between species. The organizational principles that distinguish the human brain from other species have been a long-standing enigma in neuroscience. Human pyramidal cells form highly complex networks, demonstrated by the increased number and simplex dimension compared to mice. This is unexpected because human pyramidal cells are much sparser in the cortex. The number and size of neurons fail to account for this increased network complexity, suggesting that another morphological property is a key determinant of network connectivity. By comparing the topology of dendrites, I will show that human pyramidal cells have much higher perisomatic (basal and oblique) branching density. Therefore greater dendritic complexity, a defining attribute of human L2 and 3 neurons, may provide the human cortex with enhanced computational capacity and cognitive flexibility.

In 2005, Faltings initiated a p-adic analogue of the complex Simpson correspondence, a theory that has since been explored by various authors through different approaches. In this two-lecture series (part I in the Algebra Seminar and part II in the Arithmetic Geometry Seminar), I will present a joint work in progress with Michel Gros and Takeshi Tsuji, motivated by the goal of comparing the parallel approaches we have developed and establishing a robust framework to achieve broader functoriality results for the p-adic Simpson correspondence.

The approach I developed with M. Gros relies on the choice of a first-order deformation and involves a torsor of deformations along with its associated Higgs-Tate algebra, ultimately leading to Higgs bundles. In contrast, T. Tsuji's approach is intrinsic, relying on Higgs envelopes and producing Higgs crystals. The evaluations of a Higgs crystal on different deformations differ by a twist involving a line bundle on the spectral variety.  A similar and essentially equivalent twisting phenomenon occurs in the first approach when considering the functoriality of the p-adic Simpson correspondence by pullback by a morphism that may not lift to the chosen deformations.
We introduce a novel approach to twisting Higgs modules using Higgs-Tate algebras, similar to the first approach of the p-adic Simpson correspondence. In fact, the latter can itself be reformulated as a twist. Our theory provides new twisted higher direct images of Higgs modules, that we apply to study the functoriality of the p-adic Simpson correspondence by higher direct images with respect to a proper morphism that may not lift to the chosen deformations. Along the way, we clarify the relation between our twisting and another twisting construction using line bundles on the spectral variety that appeared recently in other works.

In recent years there has been a great deal of interest in detecting properties of the fundamental group $\pi_1M$ of a $3$-manifold via its finite quotients, or more conceptually by its profinite completion.

This motivates the study of the profinite completion $\widehat {\pi_1M}$ of the fundamental group of a $3$-manifold. I shall discuss a description of the  finitely generated prosoluble subgroups of the profinite completions of all 3-manifold groups and of related groups of geometric nature.