Thu, 05 Dec 2019

11:30 - 12:30
C4

Universally defining finitely generated subrings of global fields

Nicolas Daans
(Antwerpen)
Abstract

   It is a long-standing open problem whether the ring of integers Z has an existential first-order definition in Q, the field of rational numbers. A few years ago, Jochen Koenigsmann proved that Z has a universal first-order definition in Q, building on earlier work by Bjorn Poonen. This result was later generalised to number fields by Jennifer Park and to global function fields of odd characteristic by Kirsten Eisenträger and Travis Morrison, who used classical machinery from number theory and class field theory related to the behaviour of quaternion algebras over global and local fields.


   In this talk, I will sketch a variation on the techniques used to obtain the aforementioned results. It allows for a relatively short and uniform treatment of global fields of all characteristics that is significantly less dependent on class field theory. Instead, a central role is played by Hilbert's Reciprocity Law for quaternion algebras. I will conclude with an example of a non-global set-up where the existence of a reciprocity law similarly yields universal definitions of certain subrings.

Tue, 05 Nov 2019

12:45 - 14:00
C5

Dimensionality reduction techniques for global optimization

Adilet Otemissov
(Oxford University)
Abstract

We consider the problem of global minimization with bound constraints. The problem is known to be intractable for large dimensions due to the exponential increase in the computational time for a linear increase in the dimension (also known as the “curse of dimensionality”). In this talk, we demonstrate that such challenges can be overcome for functions with low effective dimensionality — functions which are constant along certain linear subspaces. Such functions can often be found in applications, for example, in hyper-parameter optimization for neural networks, heuristic algorithms for combinatorial optimization problems and complex engineering simulations.

Extending the idea of random subspace embeddings in Wang et al. (2013), we introduce a new framework (called REGO) compatible with any global min- imization algorithm. Within REGO, a new low-dimensional problem is for- mulated with bound constraints in the reduced space. We provide probabilistic bounds for the success of REGO; these results indicate that the success is depen- dent upon the dimension of the embedded subspace and the intrinsic dimension of the function, but independent of the ambient dimension. Numerical results show that high success rates can be achieved with only one embedding and that rates are independent of the ambient dimension of the problem.

 

lin28 proteins promote expression of 17∼92 family miRNAs during amphibian development
Warrander, F Faas, L Kovalevskiy, O Peters, D Coles, M Antson, A Genever, P Isaacs, H Developmental Dynamics volume 245 issue 1 34-46 (14 Jan 2016)
Human Lin28 Forms a High-Affinity 1:1 Complex with the 106~363 Cluster miRNA miR-363
Peters, D Fung, H Levdikov, V Irmscher, T Warrander, F Greive, S Kovalevskiy, O Isaacs, H Coles, M Antson, A Biochemistry volume 55 issue 36 5021-5027 (13 Sep 2016)
Label-free imaging to study phenotypic behavioural traits of cells in complex co-cultures
Suman, R Smith, G Hazel, K Kasprowicz, R Coles, M O’Toole, P Chawla, S Scientific Reports volume 6 issue 1 22032 (26 Feb 2016)
Building confidence in quantitative systems pharmacology models: An engineer's guide to exploring the rationale in model design and development
Timmis, J Alden, K Andrews, P Clark, E Nellis, A Naylor, B Coles, M Kaye, P CPT Pharmacometrics & Systems Pharmacology volume 6 issue 3 156-167 (09 Mar 2017)
T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions
Teijeira, A Hunter, M Russo, E Proulx, S Frei, T Debes, G Coles, M Melero, I Detmar, M Rouzaut, A Halin, C Cell Reports volume 18 issue 4 857-865 (Jan 2017)
IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma
Pandey, S Mourcin, F Marchand, T Nayar, S Guirriec, M Pangault, C Monvoisin, C Amé-Thomas, P Guilloton, F Dulong, J Coles, M Fest, T Mottok, A Barone, F Tarte, K Blood volume 129 issue 18 2507-2518 (04 May 2017)
Subscribe to