Transdifferentiation, the process of converting from one cell type to another without going through a pluripotent state, has great promise for regenerative medicine. The identification of key transcription factors for reprogramming is limited by the cost of exhaustive experimental testing of plausible sets of factors, an approach that is inefficient and unscalable. We developed a predictive system (Mogrify) that combines gene expression data with regulatory network information to predict the reprogramming factors necessary to induce cell conversion. We have applied Mogrify to 173 human cell types and 134 tissues, defining an atlas of cellular reprogramming. Mogrify correctly predicts the transcription factors used in known transdifferentiations. Furthermore, we validated several new transdifferentiations predicted by Mogrify, including both into and out of the same cell type (keratinocytes). We provide a practical and efficient mechanism for systematically implementing novel cell conversions, facilitating the generalization of reprogramming of human cells. Predictions are made available via http://mogrify.net to help rapidly further the field of cell conversion.

Conical symplectic resolutions are one of the main objects in the contemporary mix of algebraic geometry and representation theory, 

known as geometric representation theory. They cover many interesting families of objects such as quiver varieties and hypertoric

varieties, and some simpler such as Springer resolutions. The last findings [Braverman, Finkelberg, Nakajima] say that they arise

as Higgs/Coulomb moduli spaces, coming from physics. Most of the gadgets attached to conical symplectic resolutions are rather

algebraic, such as their quatizations and $\mathcal{O}$-categories. We are rather interested in the symplectic topology of them, in particular 

finding smooth exact Lagrangians that appear in the central fiber of the (defining) resolution, as they are objects of the Fukaya category.

I am going to report on some developments in regularity theory of nonlinear, degenerate equations, with special emphasis on estimates involving linear and nonlinear potentials. I will cover three main cases: degenerate nonlinear equations, systems, non-uniformly elliptic operators.