Many biological reaction-diffusion systems are multiscale: in some regions molecules are abundant, while in others only a few are present. Where numbers are low, intrinsic noise is significant, and a stochastic model such as Gillespie's algorithm is needed to capture the fluctuations and rare events that shape the behaviour. Where numbers are high, this approach is too expensive, and a continuum PDE is sufficient.

Hybrid methods aim to apply each description where it is appropriate, but most require an explicit spatial interface separating the stochastic and deterministic regions. The Spatial Regime Conversion Method (SRCM) avoids this. Each region of space carries both discrete particles and continuous PDE mass, and moves mass between them through conversion events as local concentrations change. The method therefore adapts automatically as the system evolves, resolving stochastic detail wherever intrinsic noise matters and using the cheaper PDE everywhere else, with no fixed interface to track.

In this talk I introduce the method and show how it works, then illustrate it on examples including epidemic spread and a Turing instability driven by noise, where it reproduces the stochastic behaviour that a continuum model alone cannot capture.

One can learn a lot about a compact manifold if one can show that it fibres over the circle - in essence, this allows us to view a static n-dimensional manifold as a manifold of dimension n-1 that evolves in time.Being fibred (over the circle) is a relatively rare property. It is much more common to be virtually fibred, that is, to admit a finite cover that is fibred. For example, it was the content of a conjecture of William Thurston, now two theorems by Ian Agol and Dani Wise, that all finite-volume hyperbolic 3-manifolds are virtually fibred; in fact, this property is extremely common among irreducible 3-manifolds.The situation is less clear in higher dimensions. On the obstruction side, we know that virtually fibred manifolds must have vanishing Euler characteristic. This immediately shows that compact hyperbolic manifolds in even dimensions will not be virtually fibred. A more involved obstruction comes from L2-homology: virtually fibred manifolds must be L2-acyclic. The motivation behind the research I will present lies in trying to find situations in which the vanishing of L2-homology is is not only necessary, but also sufficient for virtual fibring. It turns our that a lot more can be said if we replace aspherical manifolds by their homological cousins: Poincare duality groups. Concretely, if G is an n-dimensional Poincare-duality group over the rationals, and if G satisfies the RFRS property, then G is L2-acyclic if and only if there is a finite-index subgroup G0 of G and an epimorphism from G0 onto the integers such that its kernel is a Poincare-duality group over the rationals of dimension n-1. (This last theorem is joint with Sam Fisher and Giovanni Italiano.)The RFRS property was introduced in Agol's work on Thurston's conjecture. A countable group is RFRS if and only if it is residually {virtually abelian and poly-Z}. All compact special groups in the sense of Haglund-Wise satisfy this property, so there is a ready supply of RFRS groups, also among fundamental groups of hyperbolic manifolds in high dimensions.

The talk gives some survey about recent applications of finitely additive measures to Lebesgue integrable functions. After a short introduction to such measures and related integrals, purely finitely additive measures are of particular interest. Special examples are given and, as a first application, an integral representation for the precise representative of Lebesgue integrable functions is provided. Then, based on a general approach to traces, a new version of the Gauss-Green formula is introduced, where neither a pointwise trace nor a pointwise normal is needed on the boundary. This allows e.g. the treatment of inner boundaries and of concentrations on the boundary. A second boundary integral is used to handle singularities that hadnot been accessible before. Finally, weak versions of differentiability for Lebesgue integrable functions are discussed, a mean value formula for a class of Sobolev functions is given, and a new approach to the generalized derivatives in the sense of Clarke is provided.