Indiana University

Creating networks of statistical dependencies between brain regions is a powerful tool in neuroscience that has resulted in many new insights and clinical applications. However, recent interest in higher-order interactions has highlighted the need to address beyond-pairwise dependencies in brain activity. Multivariate information theory is one tool for identifying these interactions and is unique in its ability to distinguish between two qualitatively different modes of higher-order interactions: synergy and redundancy. I will present results from applying the O-information, the partial entropy decomposition, and the local O-information to resting state fMRI data. Each of these metrics indicate that higher-order interactions are widespread in the cortex, and further that they reveal different patterns of statistical dependencies than those accessible through pairwise methods alone. We find that highly synergistic subsystems typically sit between canonical functional networks and incorporate brain regions from several of these systems. Additionally, canonical networks as well as the interactions captured by pairwise functional connectivity analyses, are strongly redundancy-dominated. Finally, redundancy/synergy dominance varies in both space and time throughout an fMRI scan with notable recurrence of sets of brain regions engaging synergistically. As a whole, I will argue that higher-order interactions in the brain are an under-explored space that, made accessible with the tools of multivariate information theory, may offer novel insights.

The cobordism hypothesis gives a correspondence between the
framed local topological field theories with values in C and a fully
dualizable objects in C.  Changing framing gives an O(n) action on the
space of local TFTs, and hence by the cobordism hypothesis it gives a
(homotopy coherent) action of O(n) on the space of fully dualizable
objects in C.  One example of this phenomenon is that O(3) acts on the
space of fusion categories.  In fact, O(3) acts on the larger space of
finite tensor categories.  I'll describe this action explicitly and
discuss its relationship to the double dual, Radford's theorem,
pivotal structures, and spherical structures.  This is part of work in
progress joint with Chris Douglas and Chris Schommer-Pries.
 

Now that the "classical" philosophies that have danced attendance upon intuitionistic mathematics (Brouwer's subjectivism, Heyting's eclecticism, and contemporary anti-realism) are recognized as failures, it is encumbent upon intuitionists to develop new foundations for their mathematics. In this talk, we assay such efforts, in particular, investigations into the various mathematical grounds on the basis of which the law of the excluded third might be proven invalid. It will also be necessary, along the way, to explode certain mistaken ideas about intuitionism, among them the notion that the logical signs of the intuitionists bear meanings different from those attached to the corresponding signs in conventional mathematics.

Please let Bruno Whittle (@email) know if you would like to go out to dinner with the speaker after the seminar.