Queen Mary University

We consider the varifolds associated to phase transitions whose first variation of Allen-Cahn energy is $L^p$ integrable with respect to the energy measure. We can see that the Dirichlet and potential part of the energy are almost equidistributed. After passing to the phase field limit, one can obtain an integer rectifiable varifold with bounded $L^p$ mean curvature. This is joint work with Huy Nguyen.

The sinoatrial node (SAN) is the pacemaker region of the heart.
Recently calcium signals, believed to be crucially important in heart
rhythm generation, have been imaged in intact SAN and shown to be
heterogeneous in various regions of the SAN. However, calcium imaging
is noisy, and the calcium signal heterogeneity has not been
mathematically analyzed to distinguish meaningful signals from
randomness or to identify signalling regions in an objective way. In
this work we apply methods of random matrix theory (RMT) developed for
financial data and used for analysis of various biological data sets
including β-cell collectives and EEG data. We find eigenvalues of the
correlation matrix that deviate from RMT predictions, and thus are not
explained by randomness but carry additional meaning. We use
localization properties of the eigenvectors corresponding to high
eigenvalues to locate particular signalling modules. We find that the
top eigenvector captures a common response of the SAN to action
potential. In some cases, the eigenvector corresponding to the second
highest eigenvalue appears to yield a possible pacemaker region as its
calcium signals predate the action potential. Next we study the
relationship between covariance coefficients and distance and find
that there are long range correlations, indicating intercellular
interactions in most cases. Lastly, we perform an analysis of nearest
neighbor eigenvalue distances and find that it coincides with the
universal Wigner surmise. On the other hand, the number variance,
which captures eigenvalue correlations, is a parameter that is
sensitive to experimental conditions. Thus RMT application to SAN
allows to remove noise and the global effects of the action potential
and thereby isolate the correlations in calcium signalling which are
local. This talk is based on joint work with Chloe Norris with a
preprint found here:
https://www.biorxiv.org/content/10.1101/2022.02.25.482007v1.

Spatial networks are often the most natural way to represent spatial information of different kinds. One of the outstanding problems in current spatial network research is to effectively quantify the heterogeneity of the discrete-valued spatial distributions underlying a spatial graph. In this talk we will presentsome recent alternative approaches to estimate heterogeneity in spatial networks based on simple dynamical processes running on them.

Suppose we have a finite graph. We can view this as a resistor network where each edge has unit resistance. We can then calculate the resistance between any two vertices and ask questions like `which graph with $n$ vertices and $m$ edges minimises the average resistance between pairs of vertices?' There is a `obvious' solution; we show that this answer is not correct.

This problem was motivated by some questions about the design of statistical experiments (and has some surprising applications in chemistry) but this talk will not assume any statistical knowledge.

This is joint work with Robert Johnson.